Cancer Biomarkers in Body Fluids

Principles

Authors: Dakubo, Gabriel D

  • Presents cancer biomarkers for noninvasive diagnosis of 18 different body fluids
  • Shows prosprectives for a coordinated validation of cancer biomarkers by industries, regulatory bodies, and academics for clinical translation
  • Presents opportunities for cancer personalized medicine ​
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-01580-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.00
price for USA
  • ISBN 978-3-319-01579-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the “liquid biopsy” concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well.

This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.​​

About the authors

Dr. Gabriel D. Dakubo is an Assistant Professor of Molecular Medicine and Human Anatomy in the Division of Medical Sciences at the Northern Ontario School of Medicine. He received his BSc and MBChB degrees from the University of Ghana, followed by the pursuance of a Postdoctoral research fellowship in Molecular Medicine at the Ottawa Hospital Research Institute, Canada. Dr. Dakubo’s passion is in noninvasive deployment of biomarkers for cancer management. While an expert in mitochondrial genetic alterations in cancer, he also has a keen interest in the inter-genomic communications that occur in the cancer cell, as well as the Slaughter’s concept of field cancerization. Dr. Dakubo is well published, and has reviewed for a number of esteemed journals, including Clinical Cancer Research.

Table of contents (11 chapters)

  • Molecular Pathology of Cancer

    Dakubo, Gabriel D.

    Pages 1-54

  • Advanced Technologies for Body Fluid Biomarker Analyses

    Dakubo, Gabriel D.

    Pages 55-74

  • Liquid Biopsy and Cancer Biomarkers

    Dakubo, Gabriel D.

    Pages 75-102

  • Methylated DNA as Cancer Biomarkers in Circulation

    Dakubo, Gabriel D.

    Pages 103-123

  • Nucleic Acids as Cancer Biomarkers in Circulation

    Dakubo, Gabriel D.

    Pages 125-152

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-01580-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.00
price for USA
  • ISBN 978-3-319-01579-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cancer Biomarkers in Body Fluids
Book Subtitle
Principles
Authors
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-01580-4
DOI
10.1007/978-3-319-01580-4
Hardcover ISBN
978-3-319-01579-8
Edition Number
1
Number of Pages
XVI, 299
Number of Illustrations and Tables
2 b/w illustrations, 44 illustrations in colour
Topics