The Genetics of Type 2 Diabetes and Related Traits

Biology, Physiology and Translation

Editors: Florez, Jose C. (Ed.)

  • Presents the state of the art of diabetes genetics
  • Covers all aspects from genetic discovery to interpretation and clinical application
  • Illustrates a model for other complex human phenotypes
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About this book

This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future. 
 

About the authors

Jose C. Florez, M.D., Ph.D. is the Chief of the Diabetes Unit at the Massachusetts General Hospital, an Associate Professor at Harvard Medical School, and an Institute Member at the Broad Institute, where he leads the Diabetes Research Group, co-leads the Program in Metabolism, and is active in the Program in Medical and Population Genetics.

He and his group have contributed to the performance and analysis of high-throughput genome-wide association and sequencing studies in type 2 diabetes and related traits, in the Diabetes Genetics Initiative, the Framingham Heart Study, and other international consortia such as MAGIC, GENIE, DIAGRAM, T2D-GENES and SIGMA, where he plays management roles. He leads the genetic research efforts of the Diabetes Prevention Program, where the effects of genetic variants on the development of diabetes can be examined prospectively, and their impact on specific behavioral and pharmacological preventive interventions can be assessed. He is the Principal Investigator of the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH), and also conducts other pharmacogenetic studies at MGH. He is an author on 135+ original publications and 40+ reviews/book chapters.

In addition to his research and teaching duties, he is clinically active in the MGH Diabetes Center, the Endocrine inpatient consult service, and the Down Syndrome Program. He serves on the Editorial Boards for Human Genetics and the Journal of Clinical Endocrinology and Metabolism, and has been on Editorial Boards for Diabetes and Diabetologia; he is also the Editor-in-Chief for Current Diabetes Reports. He is the recipient of the MGH Physician Scientist Development Award, a Doris Duke Charitable Foundation Clinical Scientist Development Award, the MGH Department of Medicine Stephen Krane Award, the MGH Research Scholars Award, and the 2010 Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers.


Table of contents (27 chapters)

  • Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes

    Bonnefond, Amélie (et al.)

    Pages 3-12

  • Genome-Wide Association Studies of Type 2 Diabetes

    Sladek, Rob (et al.)

    Pages 13-61

  • Genome-Wide Association Studies of Quantitative Glycaemic Traits

    Barroso, Inês (et al.)

    Pages 63-89

  • Genome-Wide Association Studies (GWAS) of Adiposity

    Ingelsson, Erik (et al.)

    Pages 91-109

  • Sequencing Approaches to Type 2 Diabetes

    Kleinberger, Jeffrey W. (et al.)

    Pages 111-126

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-319-01574-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-319-01573-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Genetics of Type 2 Diabetes and Related Traits
Book Subtitle
Biology, Physiology and Translation
Editors
  • Jose C. Florez
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-01574-3
DOI
10.1007/978-3-319-01574-3
Hardcover ISBN
978-3-319-01573-6
Edition Number
1
Number of Pages
XI, 576
Number of Illustrations and Tables
40 b/w illustrations, 13 illustrations in colour
Topics