Springer Theses

Structural and Functional Characterization of the Immunoproteasome

Authors: Huber, Eva Maria

  • Nominated as an outstanding Ph.D. thesis by the Technische Universität München, Germany
  • Detailed analysis of the X-ray structures of the murine immune- and constitutive proteasome
  • Yeast mutagenesis study to explore the differences between the constitutive proteasome, the immunoproteasome and the thymoproteasome
  • Inhibition studies on the immunoproteasome-selective compound ONX 0914
see more benefits

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-3-319-01556-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA
  • ISBN 978-3-319-01555-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $99.00
price for USA
  • ISBN 978-3-319-37810-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

About the authors

Eva Huber studied biochemistry at the Technische Universität München (TUM) from 2004 till 2009. For her master studies, which were funded by the Studienstiftung des deutschen Volkes, she received the Jürgen-Manchot Studienpreis from the faculty of chemistry of the TUM. During her postgraduate studies (2009-2013) in the group of Prof. Groll at the TUM she succeeded in the elucidation of the mouse immuno- and constitutive proteasome X-ray structures in their unliganded state and in complex with the immunoproteasome-selective compound ONX 0914. For these results she has been awarded the “Management Engineers Presidential Award” in 2012.

Table of contents (5 chapters)

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-3-319-01556-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA
  • ISBN 978-3-319-01555-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $99.00
price for USA
  • ISBN 978-3-319-37810-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Structural and Functional Characterization of the Immunoproteasome
Authors
Series Title
Springer Theses
Copyright
2013
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-01556-9
DOI
10.1007/978-3-319-01556-9
Hardcover ISBN
978-3-319-01555-2
Softcover ISBN
978-3-319-37810-7
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XIX, 82
Number of Illustrations and Tables
4 b/w illustrations, 29 illustrations in colour
Topics