Springer Theses

Mathematical Modelling of the Cell Cycle Stress Response

Authors: Radmaneshfar, Elahe

  • Nominated as an outstanding Ph.D. thesis by the University of Aberdeen, UK
  • Includes the first computational model of the entire cell cycle and its interaction with the osmotic stress response network
  • Presents a comprehensive model that yields a set of novel predictions to guide further experiments
  • Also applies the model's predictions to higher eukaryotes
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  • ISBN 978-3-319-00744-1
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Hardcover $129.00
price for USA
  • ISBN 978-3-319-00743-4
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  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
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  • ISBN 978-3-319-34620-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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About this book

The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle.
 
This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.
 
The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.

Table of contents (5 chapters)

  • Introduction

    Radmaneshfar, Elahe

    Pages 1-8

  • A Biological Overview of the Cell Cycle and its Response to Osmotic Stress and the $$\alpha $$ -Factor

    Radmaneshfar, Elahe

    Pages 9-26

  • ODE Model of the Cell Cycle Response to Osmotic Stress

    Radmaneshfar, Elahe

    Pages 27-70

  • Boolean Model of the Cell Cycle Response to Stress

    Radmaneshfar, Elahe

    Pages 71-87

  • Conclusion

    Radmaneshfar, Elahe

    Pages 89-91

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-00744-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-00743-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • ISBN 978-3-319-34620-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Mathematical Modelling of the Cell Cycle Stress Response
Authors
Series Title
Springer Theses
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-00744-1
DOI
10.1007/978-3-319-00744-1
Hardcover ISBN
978-3-319-00743-4
Softcover ISBN
978-3-319-34620-5
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XV, 109
Number of Illustrations and Tables
7 b/w illustrations, 29 illustrations in colour
Topics