Springer Theses

Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers

Authors: Lau, Janet T F

  • Nominated as an outstanding Ph.D. thesis by the The Chinese University of Hong Kong, People's Republic of China
  • Explores different approaches to develop phthalocyanine-based photosensitizers toward dual and targeted photodynamic therapy (PDT), with a view to improving their specific delivery to cancerous tissues and efficiency in PDT
  • Provides the grounding and stimulates further exploration in the development of smart and efficient photosentiziers for dual and targeted PDT
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eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-00708-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-00707-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • ISBN 978-3-319-03316-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Janet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, part of the results has been published in prestigious scientific journals.

Table of contents (7 chapters)

  • Introduction

    Lau, Janet T. F.

    Pages 1-33

  • A Zinc(II) Phthalocyanine Conjugated with an Oxaliplatin Derivative for Dual Chemo- and Photodynamic Therapy

    Lau, Janet T. F.

    Pages 35-48

  • Zinc(II) Phthalocyanine-Polyamine Conjugates as Efficient Photosensitizers for Photodynamic Therapy

    Lau, Janet T. F.

    Pages 49-65

  • A Redox-Responsive Silicon(IV) Phthalocyanine for Targeted Photodynamic Therapy

    Lau, Janet T. F.

    Pages 67-82

  • A Dual pH- and Redox-Responsive Phthalocyanine-Based Photosensitizer for Targeted Photodynamic Therapy

    Lau, Janet T. F.

    Pages 83-104

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-00708-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-00707-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • ISBN 978-3-319-03316-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers
Authors
Series Title
Springer Theses
Copyright
2013
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-00708-3
DOI
10.1007/978-3-319-00708-3
Hardcover ISBN
978-3-319-00707-6
Softcover ISBN
978-3-319-03316-7
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXII, 180
Topics