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New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids

  • Book
  • © 2013

Overview

Authors:
  1. Ana Escribano Cuesta

    1. Lead Optimization Fungicides, BASF SE., Ludwigshafen, Germany

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  • Nominated as an outstanding Ph.D. thesis by the Institute of Chemical Research of Catalonia, ICIQ
  • A number of important publications in high profile chemistry journals have derived from this work
  • The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Introduction

    • Ana Escribano Cuesta
    Pages 1-35

  3. Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition Versus Metathesis-Type Reactions

    • Ana Escribano Cuesta
    Pages 37-59

  4. Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes

    • Ana Escribano Cuesta
    Pages 61-103

  5. Approach Toward the Total Synthesis of Lundurines

    • Escribano Cuesta Ana
    Pages 105-189

  6. Summary and Outlook

    • Ana Escribano Cuesta
    Pages 191-195
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Keywords

About this book

Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.

Authors and Affiliations

  • Lead Optimization Fungicides, BASF SE., Ludwigshafen, Germany

    Ana Escribano Cuesta

Bibliographic Information

  • Book Title: New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids

  • Authors: Ana Escribano Cuesta

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-319-00702-1

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer International Publishing Switzerland 2013

  • Hardcover ISBN: 978-3-319-00701-4Published: 21 August 2013

  • Softcover ISBN: 978-3-319-03385-3Published: 22 August 2015

  • eBook ISBN: 978-3-319-00702-1Published: 13 August 2013

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XIII, 195

  • Topics: Organometallic Chemistry, Catalysis, Organic Chemistry

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