Springer Theses

New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids

Authors: Escribano Cuesta, Ana

  • Nominated as an outstanding Ph.D. thesis by the Institute of Chemical Research of Catalonia, ICIQ
  • A number of important publications in high profile chemistry journals have derived from this work
  • The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells
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eBook $99.00
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  • ISBN 978-3-319-00702-1
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Hardcover $129.00
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  • ISBN 978-3-319-00701-4
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About this book

Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.

Table of contents (5 chapters)

  • Introduction

    Escribano Cuesta, Ana

    Pages 1-35

  • Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition Versus Metathesis-Type Reactions

    Escribano Cuesta, Ana

    Pages 37-59

  • Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes

    Escribano Cuesta, Ana

    Pages 61-103

  • Approach Toward the Total Synthesis of Lundurines

    Escribano Cuesta, Ana

    Pages 105-189

  • Summary and Outlook

    Escribano Cuesta, Ana

    Pages 191-195

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-00702-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-00701-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
Authors
Series Title
Springer Theses
Copyright
2013
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-00702-1
DOI
10.1007/978-3-319-00702-1
Hardcover ISBN
978-3-319-00701-4
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XIII, 195
Topics