SpringerBriefs in Biometals

Iron Acquisition by the Genus Mycobacterium

History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development

Editors: Byers, B. Rowe (Ed.)

  • Demonstrates how iron sources can be used by Mycobacterium tuberculosis and other mycobacteria

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-00303-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.99
price for USA
  • ISBN 978-3-319-00302-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

Table of contents (5 chapters)

  • Introduction to the Book

    Byers, B. Rowe

    Pages 1-2

  • A History of Iron Metabolism in the Mycobacteria

    Ratledge, Colin

    Pages 3-39

  • Mycobacterial Iron Acquisition Mechanisms

    Byers, B. Rowe

    Pages 41-52

  • Siderocalin Combats Mycobacterial Infections

    Allred, Benjamin E. (et al.)

    Pages 53-64

  • Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis

    Juárez-Hernández, Raúl E. (et al.)

    Pages 65-88

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-00303-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.99
price for USA
  • ISBN 978-3-319-00302-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Iron Acquisition by the Genus Mycobacterium
Book Subtitle
History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
Editors
  • B. Rowe Byers
Series Title
SpringerBriefs in Biometals
Copyright
2013
Publisher
Springer International Publishing
Copyright Holder
The Author(s)
eBook ISBN
978-3-319-00303-0
DOI
10.1007/978-3-319-00303-0
Softcover ISBN
978-3-319-00302-3
Series ISSN
2212-9901
Edition Number
1
Number of Pages
V, 92
Number of Illustrations and Tables
30 b/w illustrations, 9 illustrations in colour
Topics