Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products

The Epothilones: An Outstanding Family of Anti-Tumor Agents

From Soil to the Clinic

Editors: Mulzer, Johann H. (Ed.)

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About this book

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

Table of contents (6 chapters)

  • General Aspects

    Höfle, Gerhard

    Pages 5-28

  • Biosynthesis and Heterologous Production of Epothilones

    Müller, Rolf

    Pages 29-53

  • Total Synthesis of Epothilones A-F

    Mulzer, Johann (et al.)

    Pages 55-133

  • Semisynthetic Derivatives of Epothilones

    Altmann, Karl-Heinz

    Pages 135-156

  • Preclinical Pharmacology and Structure-Activity Studies of Epothilones

    Altmann, Karl-Heinz

    Pages 157-220

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-211-78207-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-3-211-78206-4
  • Free shipping for individuals worldwide
  • We do not distribute this product in your location.
Softcover $249.00
price for USA
  • ISBN 978-3-211-99928-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Epothilones: An Outstanding Family of Anti-Tumor Agents
Book Subtitle
From Soil to the Clinic
Editors
  • Johann H. Mulzer
Series Title
Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products
Series Volume
90
Copyright
2009
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Vienna
eBook ISBN
978-3-211-78207-1
DOI
10.1007/978-3-211-78207-1
Hardcover ISBN
978-3-211-78206-4
Softcover ISBN
978-3-211-99928-8
Series ISSN
0071-7886
Edition Number
1
Number of Pages
IX, 260
Topics