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Birkhäuser

Function and Regulation of Cellular Systems

  • Book
  • © 2004

Overview

Editors:
  1. Andreas Deutsch

    1. Zentrum für Hochleistungsrechnen, Technische Universität Dresden, Dresden, Germany

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  2. Jonathon Howard

    1. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  3. Martin Falcke

    1. Department Theory (SF5), Hahn-Meitner-Institut Berlin, Berlin, Germany

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  4. Walter Zimmermann

    1. Theoretische Physik, Universität des Saarlandes, Saarbrücken, Germany

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  • Focuses on structural, dynamical and functional aspects of cellular systems
  • Presents corresponding experiments and mathematical models
  • Introduces recent model approaches with applications
  • Includes applied issues such as tumor cell growth, dynamics of the immune system and biotechnology

Part of the book series: Mathematics and Biosciences in Interaction (MBI)

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Table of contents (42 chapters)

  1. Front Matter

    Pages i-x
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  2. Metabolic Networks and Engineering

    1. Front Matter

      Pages 1-1
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    2. Introduction to Part I

      • Reinhart Heinrich, Thomas Höfer
      Pages 3-5

    3. A Functional Dynamics Approach to Modelling of Glycolysis

      • Finn Hynne, Sune Danø, Preben G. Sørensen
      Pages 7-18

    4. Temperature-Compensation in Biological Clocks: Models and Experiments

      • Peter Ruoff
      Pages 19-29

    5. Metabolic Control Analysis of the ATPase Network in Contracting Muscle: Regulation of Contractile Function and ATP Free Energy Potential

      • Jeroen A. L. Jeneson, Hans V. Westerhoff, Martin J. Kushmerick
      Pages 31-46

    6. En Route for Systems Biology: In Silico Pathway Analysis and Metabolite Profiling

      • Jochen Förster, Mats Åkesson, Jens Nielsen
      Pages 47-58

  3. Intracellular Signal Transduction

    1. Front Matter

      Pages 59-59
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    2. Introduction to Part II

      • Thomas Höfer, Reinhart Heinrich
      Pages 61-62

    3. Presynaptic Calcium Dynamics of Neurons in Answer to Various Stimulation Protocols

      • Michael Meyer-Hermann, Frido Erler, Gerhard Soff
      Pages 63-71

    4. Mathematical Modeling of Signaling Cascades: Principles and Future Prospects

      • Birgit Schöberl, Martin Ginkel, Ernst D. Gilles, Gertrud Müller
      Pages 73-87

    5. Collective Behavior of Membrane Channels:Electro-Physiological Studies on Gap Junctions

      • Paramita Ghosh, Debasish Bose, Subhendu Ghosh
      Pages 89-97

    6. Modelling of Periodic Intercellular Ca2+ Waves

      • Antonio Politi, Thomas Höfer
      Pages 99-110

    7. Travelling Waves as a Mechanism of Pattern Generation in Discrete Cell Lattices

      • Erik Plahte, Leiv Øyehaug
      Pages 111-118

    8. Design and Operation: Keys to Understanding Biological Systems

      • Eberhard O. Voit
      Pages 119-131

  4. Cellular Materials: Mechanics and Motility

    1. Front Matter

      Pages 133-133
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    2. Introduction to Part III

      • Erwin Frey, Wolfgang Alt
      Pages 135-137

    3. Biopolymer Dynamics

      • Chris H. Wiggins, Loïc Le Goff
      Pages 139-150

    4. Micromechanics of Molecular Motors: Experiments and Theory

      • Andrea Parmeggiani, Christoph F. Schmidt
      Pages 151-176

    5. The Role of Osteocalcin in the Remodeling of Biomimetic Hydroxyapatite-Collagen Materials for Bone Replacement

      • Wolfgang Pompe, Katharina Flade, Michael Gelinsky, Birgit Knepper-Nicolai, Antje Reinstorf
      Pages 177-183
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Keywords

About this book

Current biological research demands the extensive use of sophisticated mathematical methods and computer-aided analysis of experiments and data. This highly interdisciplinary volume focuses on structural, dynamical and functional aspects of cellular systems and presents corresponding experiments and mathematical models. The book may serve as an introduction for biologists, mathematicians and physicists to key questions in cellular systems which can be studied with mathematical models. Recent model approaches are presented with applications in cellular metabolism, intra- and intercellular signaling, cellular mechanics, network dynamics and pattern formation. In addition, applied issues such as tumor cell growth, dynamics of the immune system and biotechnology are included.

Editors and Affiliations

  • Zentrum für Hochleistungsrechnen, Technische Universität Dresden, Dresden, Germany

    Andreas Deutsch

  • Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

    Jonathon Howard

  • Department Theory (SF5), Hahn-Meitner-Institut Berlin, Berlin, Germany

    Martin Falcke

  • Theoretische Physik, Universität des Saarlandes, Saarbrücken, Germany

    Walter Zimmermann

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