Progress in Drug Research

Peptide Transport and Delivery into the Central Nervous System

Editors: Prokai, Laszlo, Prokai-Tatrai, Katalin (Eds.)

  • Discusses strategies to overcome the blood-brain-barrier
  • Comparative evaluation of the present state of drug delivery strategies
  • Biological carriers, prodrug and chemical delivery/targeting strategies are presented
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  • ISBN 978-3-0348-8049-7
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About this book

Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.

Table of contents (8 chapters)

  • Neuropeptides: general characteristics and neuropharmaceutical potential in treating CNS disorders

    Strand, Fleur L.

    Pages 1-37

  • Structural and functional aspects of the blood-brain barrier

    Begley, David J. (et al.)

    Pages 39-78

  • Peptide transport across the blood-brain barrier

    Kastin, Abba J. (et al.)

    Pages 79-100

  • Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases

    Grondin, Richard (et al.)

    Pages 101-123

  • Altering the properties of the blood-brain barrier: disruption and permeabilization

    Fortin, David

    Pages 125-154

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-0348-8049-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $299.00
price for USA
  • ISBN 978-3-0348-9420-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Peptide Transport and Delivery into the Central Nervous System
Editors
  • Laszlo Prokai
  • Katalin Prokai-Tatrai
Series Title
Progress in Drug Research
Series Volume
61
Copyright
2003
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-8049-7
DOI
10.1007/978-3-0348-8049-7
Softcover ISBN
978-3-0348-9420-3
Series ISSN
0071-786X
Edition Number
1
Number of Pages
VIII, 245
Topics