Skip to main content
SpringerLink
Log in
Birkhäuser

Oncogenes as Transcriptional Regulators

Cell Cycle Regulators and Chromosomal Translocation

  • Book
  • © 1997

Overview

Editors:
  1. M. Yaniv

    1. Dept. of Biotechnology, Institut Pasteur, Paris Cedex 15, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. J. Ghysdael

    1. CNRS UMR 146, Institut Curie, Section de Recherche, Centre Universitaire, Orsay, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Progress in Gene Expression (PRGE)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (5 chapters)

  1. Front Matter

    Pages I-XIII
    Download chapter PDF

  2. E2Fs and the Retinoblastoma Protein Family

    • Claude Sardet, Laurent LeCam, Eric Fabbrizio, Marc Vidal
    Pages 1-62

  3. Signalling to the C-terminus of p53

    • Christine Cain, Sheau-Yann Shieh, Carol Prives
    Pages 63-75

  4. Chromosome Translocations Generating Chimeric Transcription Factors, Unique Genetic Events with Pleiotropic Cellular Consequences

    • Yves Labelle, Olivier Delattre
    Pages 77-105

  5. The Runt Domain Transcription Factor, PEBP2/CBF, and its Involvement in Human Leukemia

    • Yoshiaki Ito, Suk-Chul Bae
    Pages 107-132

  6. EBNA2: A Viral Transcription Factor Essential for the Immortalization of Human B Lymphocytes by the Epstein-Barr Virus (EBV)

    • Lucas Waltzer, Fabienne Meggetto, Alain Sergeant, Evelyne Manet
    Pages 133-161

  7. Back Matter

    Pages 162-162
    Download chapter PDF
Back to top

Keywords

About this book

The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character­ ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro­ teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral­ lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper­ toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel­ opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.

Editors and Affiliations

  • Dept. of Biotechnology, Institut Pasteur, Paris Cedex 15, France

    M. Yaniv

  • CNRS UMR 146, Institut Curie, Section de Recherche, Centre Universitaire, Orsay, France

    J. Ghysdael

Bibliographic Information

  • Book Title: Oncogenes as Transcriptional Regulators

  • Book Subtitle: Cell Cycle Regulators and Chromosomal Translocation

  • Editors: M. Yaniv, J. Ghysdael

  • Series Title: Progress in Gene Expression

  • DOI: https://doi.org/10.1007/978-3-0348-8934-6

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1997

  • Hardcover ISBN: 978-3-7643-5709-2Published: 16 July 1997

  • Softcover ISBN: 978-3-0348-9833-1Published: 16 October 2012

  • eBook ISBN: 978-3-0348-8934-6Published: 27 November 2013

  • Edition Number: 1

  • Number of Pages: XIII, 162

  • Topics: Life Sciences, general, Biomedicine general

Publish with us

Policies and ethics

Back to top

Search

Navigation