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Gene Therapy

Principles and Applications

Editors: Blankenstein (Ed.)

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  • ISBN 978-3-0348-7011-5
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  • ISBN 978-3-0348-7013-9
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About this book

K. Sikora Gene therapy is one of the fastest developing areas in modern medical research. Transcending the classical preclinical and clinical disciplines, it is likely to have far­ reaching consequences in the practice of medicine, as we enter the next millennium. Currently, there are over 200 seperate active clinical trials with over 2,500 patients entered. These studies involve over 20 countries and include patients with a wide range of diseases, including cancer, HIV infection; cystic fibrosis (CF), haemophilia, diabetes, immune deficiencies, metabolic disorders, ischaemic heart disease and arthritis. Gene therapy can be defined as the deliberate transfer of DNA for therapeutic purposes. There is a further implication that only specific sequences containing rel­ evant genetic information are used; otherwise, transplantation procedures involving bone marrow, kidney or liver could be considered a form of gene therapy. The con­ cept of transfer of genetic information as a practical clinical tool arose from the gene-cloning technology, developed during the 1970s. Without the ability to isolate and replicate defined genetic sequences, it would be impossible to produce purified material for clinical use. The drive for the practical application of this technology came from the biotechnology industry with its quest for complex human biomole­ cules produced by recombinant techniques in bacteria. Within a decade, pharma­ ceutical-grade insulin, interferon, interleukin 2 and tumour necrosis factor were all involved in clinical trials. The next step was to obtain gene expression in vivo.

Table of contents (22 chapters)

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-0348-7011-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $129.00
price for USA
valid through October 16, 2017
  • ISBN 978-3-0348-7013-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gene Therapy
Book Subtitle
Principles and Applications
Editors
  • Blankenstein
Copyright
1999
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Verlag
eBook ISBN
978-3-0348-7011-5
DOI
10.1007/978-3-0348-7011-5
Softcover ISBN
978-3-0348-7013-9
Edition Number
1
Number of Pages
XII, 380
Topics