Effectors of Thermogenesis

1. Front Matter

   Pages 1-17

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2. Control Mechanisms of Energy Dissipation in the Cytomembrane and Cytosol

   1. Plasma Membrane Involvement in Brown Fat Thermogenesis

      • Barbara A. Horwitz

      Pages 19-23

   2. Does Cytoplasmic Alkalinization Trigger Mitochondrial Energy Dissipation in the Brown Adipocyte?

      • A. Chinet, C. Friedli, J. Seydoux, L. Girardier

      Pages 25-32

   3. Thresholds for Na+ and Ca++ Effects on Thermoregulation

      • John E. Greenleaf

      Pages 33-44

   4. Catechol-O-Methyl Transferase Activity in Whole Brown Adipose Tissue of Rat in Vitro

      • Jacques Durand, Jean-Paul Giacobino, Lucien Girardier

      Pages 45-53

   5. β-Adrenergic Receptors in Brown Adipose Tissue: Identification by (-)[3H]Dihydroalprenolol Binding

      • L. J. Bukowiecki, M. G. Caron, J. Vallieres, J. LeBlanc

      Pages 55-59

   6. Control of Phosphoenolpyruvate Carboxykinase in Brown Adipose Tissue of Infant Rats

      • Peter Hahn, David Seccombe, Lorne Kirby, Josef Skala

      Pages 61-67

   7. The “Second Messenger” System in Brown Adipose Tissue of Developing Rats. Its Molecular Composition and Mechanism of Function

      • Josef P. Skala, Peter Hahn, Brian L. Knight

      Pages 69-74

3. Control Mechanisms of Energy Dissipation in the Mitochondria

   1. Energy Dissipation in Brown Adipose Tissue Mitochondria

      • Johannes Rafael

      Pages 75-87

   2. The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation

      • David G. Nicholls, Vibeke S. M. Bernson, Gillian M. Heaton

      Pages 89-93

   3. Polyamine and Magnesium Effects on Mitochondrial Respiration in Control and Heat-Acclimated Rats

      • Rowand R. J. Chaffee, Robert M. Rochelle Arine, H. Rene, Charles D. Walker

      Pages 95-99

   4. Succinate Oxidation in Hamster Brown Adipocytes

      • Bertil Pettersson, Per Lundberg, Vibeke S. M. Bernson

      Pages 101-105

   5. Energy Dissipation in Brown Fat

      • Barbara Cannon, Jan Nedergaard

      Pages 107-111

   6. 6-OH-Dopamine and the Development of Brown Adipose Tissue in the Cold

      • G. Mory, M. Nechad, D. Ricquier, Ph. Hemon

      Pages 113-117

4. Endocrine and Neural Control of Energy Dissipation

   1. Thermogenic Mechanisms and their Control

      • Jean Himms-Hagen, J. Cerf, M. Desautels, Gloria Zaror-Behrens

      Pages 119-134

   2. Levels of Noradrenaline in Plasma During Thermogenesis Induced by Cold-Exposure or by Noradrenaline Infusion in Warm- and in Cold-Acclimated Rats

      • Florent Depocas, Willy A. Behrens

      Pages 135-146

   3. Brown Adipose Tissue: The Dominant Site of Nonshivering Thermogenesis in the Rat

      • David O. Foster, M. Lorraine Frydman

      Pages 147-151

   4. Control of Brown Fat Thermogenesis by the Sympathetic Nervous System

      • Josiane Seydoux, Lucien Girardier

      Pages 153-167

   5. Hormonal Thermogenesis of “Non-Norepinephrine” Type

      • Ladislav Jansky

      Pages 169-175

   6. “Cascade” Principle of the Control of Non-Shivering Thermogenesis by Intravenously Infused Noradrenaline

      • Jiři A. Mejsnar

      Pages 177-183

One of the most interesting aspects of thermogenesis research is that it quite naturally attracts workers from an extremely wide spectrum of interests, ranging from the mechanism of cellular respiratory control at the molecular level and neuro-hormonal control of energy dissipation both at the cellular level and that of the whole organisms to the mechanism of temperature control during the hibernating cycle and that of cold acclimatation. Thus, the Satellite Symposium on "The Effectors of Thermogenesis" brought together not only physiologists, but also biochemists, pharmacologists, zoologists and clinicians, and provided a forum for the airing of new ideas as well as for the confrontation of different points of view. These are now reproduced in this book in exactly the same form and order in which they were presented at the Symposium, in the hope of providing a bird's-eye view of the various facets of thermogenesis research. A "mini-review", summarizing the current knowledge in each domain, therefore precedes the corresponding papers. The editors are deeply indebted to the contributors of these introductory lectures for so competently selecting from the mass of available information in each field, only the most essential elements. This book is dedicated to Dr. Robert Emrie Smith, a pioneer and path-finder in this field, who organized the first meeting on thermogenesis as a satellite of the XXI International Congress of Physiological Sciences and took an active part in the four subsequent meetings. L. Girardier DEDICATION Dr.

• adaptation
• cell membrane
• dopamine
• enzymes
• Glucocorticoid
• Hormone
• Lipoprotein
• metabolism
• Nucleotide
• nutrition
• pharmacology
• research
• Respiration
• skeletal muscle
• tissue

• Department of Physiology, Medical School, Geneva, Switzerland

  L. Girardier, J. Seydoux

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