Experientia Supplementum

T Lymphocytes as Tools in Diagnostics and Immunotoxicology

Editors: Martin, Stefan F. (Ed.)

  • Alternative assays for the detection of contact allergens and drug metabolites
  • Summarizes the state-of-the art
  • Written by experts in the field
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-0348-0726-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-0348-0725-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods.

The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.

Table of contents (11 chapters)

  • The Use of T Cells in Hazard Characterization of Chemical and Drug Allergens and Integration in Testing Strategies

    Kimber, Ian (et al.)

    Pages 1-7

  • Activation of the TCR Complex by Peptide-MHC and Superantigens

    Louis-Dit-Sully, Christine (et al.)

    Pages 9-23

  • Activation of the TCR Complex by Small Chemical Compounds

    Louis-Dit-Sully, Christine (et al.)

    Pages 25-39

  • T Cell Responses to Contact Allergens

    Weltzien, Hans Ulrich (et al.)

    Pages 41-49

  • Contact Hypersensitivity: Quantitative Aspects, Susceptibility and Risk Factors

    Friedmann, Peter S. (et al.)

    Pages 51-71

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-0348-0726-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-0348-0725-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
T Lymphocytes as Tools in Diagnostics and Immunotoxicology
Editors
  • Stefan F. Martin
Series Title
Experientia Supplementum
Series Volume
104
Copyright
2014
Publisher
Springer Basel
Copyright Holder
Springer Basel
eBook ISBN
978-3-0348-0726-5
DOI
10.1007/978-3-0348-0726-5
Hardcover ISBN
978-3-0348-0725-8
Series ISSN
1023-294X
Edition Number
1
Number of Pages
VI, 184
Number of Illustrations and Tables
6 b/w illustrations, 21 illustrations in colour
Topics