Milestones in Drug Therapy

Indacaterol

The First Once-daily Long-acting Beta2 Agonist for COPD

Editors: Trifilieff, Alexandre (Ed.)

  • Summarizes preclinical and clinical data
  • A valuable source of information for scientists and clinicians
  • Contemporary monograph on the pharmacotherapy of COPD
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-0348-0709-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-0348-0708-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available.

This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled β2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.

Table of contents (9 chapters)

  • Current Pharmacotherapy for COPD

    Donohue, James F. (et al.)

    Pages 1-23

  • The Preclinical Pharmacology of Indacaterol

    Trifilieff, Alexandre (et al.)

    Pages 25-37

  • The Design of the Indacaterol Molecule

    Fairhurst, Robin A. (et al.)

    Pages 39-65

  • The Early Clinical Development of Indacaterol

    Beier, Jutta (et al.)

    Pages 67-76

  • INHANCE: An Adaptive Confirmatory Study with Dose Selection at Interim

    Lawrence, David (et al.)

    Pages 77-92

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-0348-0709-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-0348-0708-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Indacaterol
Book Subtitle
The First Once-daily Long-acting Beta2 Agonist for COPD
Editors
  • Alexandre Trifilieff
Series Title
Milestones in Drug Therapy
Copyright
2014
Publisher
Springer Basel
Copyright Holder
Springer Basel
eBook ISBN
978-3-0348-0709-8
DOI
10.1007/978-3-0348-0709-8
Hardcover ISBN
978-3-0348-0708-1
Series ISSN
2296-6056
Edition Number
1
Number of Pages
VII, 146
Number of Illustrations and Tables
20 b/w illustrations, 21 illustrations in colour
Topics