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Drugs Targeting B-Cells in Autoimmune Diseases

  • Book
  • © 2014

Overview

Editors:
  1. Xavier Bosch

    1. Hospital Clinic, Department of Internal Medicine, University of Barcelona, Barcelona, Spain

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    You can also search for this editor in PubMed   Google Scholar

  2. Manuel Ramos-Casals

    1. Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain

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    You can also search for this editor in PubMed   Google Scholar

  3. Munther A Khamashta

    1. King's College, The Rayne Institute, St. Thomas' Hospital, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • Written and edited by leading international experts with long clinical experience
  • Provides comprehensive background and practical information for scientists, clinicians and pharmaceutical companies
  • Improves the understanding of and the decision for this new therapies of autoimmune diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
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  2. Historic Outline of the Development of Drugs Targeting B Cells

    • Maria J. Leandro
    Pages 1-10

  3. Understanding B Cell Biology

    • Martin S. Naradikian, Jean L. Scholz, Michael A. Oropallo, Michael P. Cancro
    Pages 11-35

  4. Pharmacological Effects and Mechanisms of Action of Agents Blocking B Cells

    • Ignacio Sanz
    Pages 37-64

  5. Systemic Lupus Erythematosus: Direct B-Cell Blocking

    • Maria Ahijón Lana, Zozik Fattah, Susana Araujo Fernandez, David A. Isenberg
    Pages 65-78

  6. Systemic Lupus Erythematosus: Indirect B-Cell Blocking

    • Pilar Brito-Zerón, Ma José Soto-Cárdenas, Soledad Retamozo, Xavier Bosch, Manuel Ramos-Casals, Munther A. Khamashta
    Pages 79-95

  7. B-Cell Targeted Therapies in Rheumatoid Arthritis

    • Stephan Blüml, Georg Stummvoll, Josef S. Smolen
    Pages 97-110

  8. B-Cell Targeted Therapies in Primary Sjögren Syndrome

    • Pilar Brito-Zerón, Antoni Sisó-Almirall, Belchin Kostov, Xavier Bosch, Athanasios G. Tzioufas, Manuel Ramos-Casals
    Pages 111-138

  9. Targeting B Cells in ANCA-Associated Vasculitides

    • Xavier Bosch, John H. Stone
    Pages 139-152

  10. B-Cell Targeted Therapies in Systemic Sclerosis and Inflammatory Myopathies

    • Rohit Aggarwal, Vivek Nagaraja, Dinesh Khanna
    Pages 153-180

  11. B-Cell Targeted Therapies in Cryoglobulinemia

    • Salvatore De Vita
    Pages 181-191

  12. B-Cell Targeted Therapies in Autoimmune Cytopenias and Thrombosis

    • Bassem N. Matta, Rabih Nayfe, Ali T. Taher, Imad Uthman
    Pages 193-217

  13. Targeting B Cells in Neurological Autoimmune Diseases

    • Maria Sepúlveda, Albert Saiz, Francesc Graus
    Pages 219-246

  14. Targeting B Cells in Other Systemic Autoimmune Diseases

    • Xavier Bosch, Pilar Brito-Zerón, Munther A. Khamashta, Manuel Ramos-Casals
    Pages 247-258

  15. Safety of B-Cell Targeted Therapies

    • Ian N. Bruce
    Pages 259-276

  16. The Future Potential of Biosimilars Targeting B-Cells

    • Savino Sciascia, Dario Roccatello, Chary Lopez-Pedrera, Maria Jose’ Cuadrado
    Pages 277-284

  17. Back Matter

    Pages 285-292
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Keywords

About this book

This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.

Editors and Affiliations

  • Hospital Clinic, Department of Internal Medicine, University of Barcelona, Barcelona, Spain

    Xavier Bosch

  • Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain

    Manuel Ramos-Casals

  • King's College, The Rayne Institute, St. Thomas' Hospital, London, United Kingdom

    Munther A Khamashta

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