SpringerBriefs in Biochemistry and Molecular Biology

Gamma-Glutamyl Transpeptidases

Structure and Function

Authors: Castellano, Immacolata, Merlino, Antonello

  • Comprehensive, up-to-date overview

Buy this book

eBook $54.99
price for USA (gross)
  • ISBN 978-3-0348-0682-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $69.99
price for USA
  • ISBN 978-3-0348-0681-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

 Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.​

Table of contents (1 chapters)

  • Gamma-Glutamyl Transpeptidases: Structure and Function

    Castellano, Immacolata (et al.)

    Pages 1-57

Buy this book

eBook $54.99
price for USA (gross)
  • ISBN 978-3-0348-0682-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $69.99
price for USA
  • ISBN 978-3-0348-0681-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Gamma-Glutamyl Transpeptidases
Book Subtitle
Structure and Function
Authors
Series Title
SpringerBriefs in Biochemistry and Molecular Biology
Copyright
2013
Publisher
Springer Basel
Copyright Holder
The Author(s)
eBook ISBN
978-3-0348-0682-4
DOI
10.1007/978-3-0348-0682-4
Softcover ISBN
978-3-0348-0681-7
Series ISSN
2211-9353
Edition Number
1
Number of Pages
VIII, 57
Number of Illustrations and Tables
10 b/w illustrations, 18 illustrations in colour
Topics