Progress in Inflammation Research

Antimicrobial Peptides and Innate Immunity

Editors: Hiemstra, Pieter S., Zaat, Sebastian A. J. (Eds.)

  • Provides a comprehensive overview on these endogenous antibiotics
  • Includes information on role in inflammatory diseases and gives an outlook on new therapeutic options
  • Written by experts in the field of antimicrobial/host defense peptide research
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  • ISBN 978-3-0348-0541-4
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Hardcover $219.00
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  • ISBN 978-3-0348-0540-7
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About this book

Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic.

The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair.  Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.

Table of contents (14 chapters)

  • Evolution of Antimicrobial Peptides: A View from the Cystine Chapel

    Lehrer, Robert I.

    Pages 1-27

  • Innate Immunity in Plants: The Role of Antimicrobial Peptides

    Stotz, H. U. (et al.)

    Pages 29-51

  • Antimicrobial Peptides Produced by Microorganisms

    Paiva, Aline Dias (et al.)

    Pages 53-95

  • LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide

    Beaumont, Paula E. (et al.)

    Pages 97-121

  • Wound Repair and Antimicrobial Peptides

    Ståhle, Mona

    Pages 123-139

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-3-0348-0541-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-0348-0540-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Antimicrobial Peptides and Innate Immunity
Editors
  • Pieter S. Hiemstra
  • Sebastian A. J. Zaat
Series Title
Progress in Inflammation Research
Copyright
2013
Publisher
Springer Basel
Copyright Holder
Springer Basel
eBook ISBN
978-3-0348-0541-4
DOI
10.1007/978-3-0348-0541-4
Hardcover ISBN
978-3-0348-0540-7
Edition Number
1
Number of Pages
XI, 384
Number of Illustrations and Tables
23 b/w illustrations, 20 illustrations in colour
Topics