SpringerBriefs in Biochemistry and Molecular Biology

Lentiviral Vectors and Gene Therapy

Authors: Escors, D., Breckpot, K., Arce, F., Kochan, G., Stephenson, H.

  • Concise overview of the development of lentivectors and gene therapy, integrating historical facts, the development and experimental application of lentivectors
  • Ideal introduction and book of reference for researchers, academics and students interested in this field
  • Each chapter can be read independently
  • Includes the very latest human clinical trials  
  • Thorough treatise on an emerging subject​
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eBook $34.99
price for USA (gross)
  • ISBN 978-3-0348-0402-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.95
price for USA
  • ISBN 978-3-0348-0401-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success.

This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.

Table of contents (6 chapters)

  • Introduction to Gene Therapy

    Escors, David (et al.)

    Pages 1-10

  • Development of Retroviral and Lentiviral Vectors

    Escors, David (et al.)

    Pages 11-28

  • Cell and Tissue Gene Targeting with Lentiviral Vectors

    Escors, David (et al.)

    Pages 29-50

  • Immunomodulation by Genetic Modification Using Lentiviral Vectors

    Arce, Frederick (et al.)

    Pages 51-67

  • Clinical Grade Lentiviral Vectors

    Kochan, Grazyna (et al.)

    Pages 69-85

Buy this book

eBook $34.99
price for USA (gross)
  • ISBN 978-3-0348-0402-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.95
price for USA
  • ISBN 978-3-0348-0401-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Lentiviral Vectors and Gene Therapy
Authors
Series Title
SpringerBriefs in Biochemistry and Molecular Biology
Copyright
2012
Publisher
Springer Basel
Copyright Holder
The Author(s)
eBook ISBN
978-3-0348-0402-8
DOI
10.1007/978-3-0348-0402-8
Softcover ISBN
978-3-0348-0401-1
Series ISSN
2211-9353
Edition Number
1
Number of Pages
IX, 104
Number of Illustrations and Tables
1 b/w illustrations, 9 illustrations in colour
Topics