Experientia Supplementum

Matrix Metalloproteinase Inhibitors

Specificity of Binding and Structure-Activity Relationships

Editors: Gupta, Satya Prakash (Ed.)

  • Focus on quantitative structure-activity relationship of MMP inhibitors
  • Contains an overview of endogenous tissue inhibitors of MMPs and their biological relevance
  • Written by experts in the field
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eBook $199.00
price for USA (gross)
  • ISBN 978-3-0348-0364-9
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Hardcover $259.00
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  • ISBN 978-3-0348-0363-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
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  • ISBN 978-3-0348-0764-7
  • Free shipping for individuals worldwide
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About this book

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases.

 

The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.

Table of contents (7 chapters)

  • Matrix Metalloproteinases

    Vargová, Viola (et al.)

    Pages 1-33

  • Specificity of Binding with Matrix Metalloproteinases

    Gupta, Satya P. (et al.)

    Pages 35-56

  • The Gelatinases and Their Inhibitors: The Structure–Activity Relationships

    Swarnakar, Snehasikta (et al.)

    Pages 57-82

  • Advances in Studies on Collagenase Inhibitors

    Yadav, Mange Ram (et al.)

    Pages 83-135

  • Hydroxamic Acids as Matrix Metalloproteinase Inhibitors

    Verma, Rajeshwar P.

    Pages 137-176

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-0348-0364-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-0348-0363-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-0348-0764-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Matrix Metalloproteinase Inhibitors
Book Subtitle
Specificity of Binding and Structure-Activity Relationships
Editors
  • Satya Prakash Gupta
Series Title
Experientia Supplementum
Series Volume
103
Copyright
2012
Publisher
Springer Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-0364-9
DOI
10.1007/978-3-0348-0364-9
Hardcover ISBN
978-3-0348-0363-2
Softcover ISBN
978-3-0348-0764-7
Series ISSN
1023-294X
Edition Number
1
Number of Pages
X, 286
Topics