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Replicating Vaccines

A New Generation

  • Book
  • © 2011

Overview

Editors:
  1. Philip R. Dormitzer

    1. Novartis Vaccines & Diagnostics, Cambridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Christian W. Mandl

    1. Novartis Vaccines & Diagnostics, Inc., Cambridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Rino Rappuoli

    1. Novartis Vaccines & Diagnostics S.r.l., Siena, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Highlights new approaches to the generation of live vaccines

  • Includes discussion of risks and safety aspects

  • Covers a variety of infectious organisms

  • Includes supplementary material: sn.pub/extras

Part of the book series: Birkhäuser Advances in Infectious Diseases (BAID)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Today’s Live Attenuated Vaccines

    1. Front Matter

      Pages 1-1
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  3. Today’s live attenuated vaccines

    1. Live Vaccines and Their Role in Modern Vaccinology

      • Gordon Dougan, David Goulding, Lindsay J. Hall
      Pages 3-14

    2. Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus

      • Harry B. Greenberg, Ann M. Arvin
      Pages 15-46

    3. Classical Live Viral Vaccines

      • Thomas
      Pages 47-69

  4. Genetically Attenuated Micro-Organisms as Vaccines

    1. Front Matter

      Pages 71-71
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  5. Genetically attenuated micro-organisms as vaccines

    1. Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus

      • Luis Enjuanes, Jose L. Nieto-Torres, Jose M. Jimenez-Guardeño, Marta L. DeDiego
      Pages 73-97

    2. Live-Attenuated Shigella Vaccines. Is Encouraging Good Enough?

      • Yves Germani, Philippe J. Sansonetti
      Pages 99-117

    3. New Generation BCG Vaccines

      • Michael V. Tullius, Marcus A. Horwitz
      Pages 119-169

  6. Manipulating Host-Pathogen Interactions to Make Vaccines

    1. Front Matter

      Pages 171-171
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  7. Manipulating host-pathogen interactions to make vaccines

    1. Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines

      • Norbert Tautz, Gregor Meyers
      Pages 173-193

    2. Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation

      • Natalie Pica, Peter Palese, John Steel
      Pages 195-221

    3. An Attenuated HSV-1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell-to-Cell and Neuronal Spread

      • Elizabeth E. Zumbrun, Harvey M. Friedman
      Pages 223-236

    4. Live Attenuated Vaccines for Respiratory Syncytial Virus

      • Michael N. Teng
      Pages 237-259

    5. Live Attenuated Cholera Vaccines: Flagella and Reactogenicity

      • D. Ewen Cameron, John J. Mekalanos
      Pages 261-281

  8. New Types of Replicating Vaccines

    1. Front Matter

      Pages 283-283
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  9. New types of replicating vaccines

    1. Replication-Defective Herpes Simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors

      • David M. Knipe
      Pages 285-298

    2. Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines

      • Justin A. Roby, Roy A. Hall, Alexander A. Khromykh
      Pages 299-320

    3. Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines

      • Juergen Stech, Hans-Dieter Klenk
      Pages 321-330

    4. Alphavirus Particle-Based Vaccine Vectors

      • Scott J. Balsitis, Clayton W. Beard, Peter W. Mason
      Pages 331-347
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Keywords

About this book

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

Reviews

From the reviews:

“This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. … Given the renaissance in vaccinology this is a timely volume which … makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field.” (Paul Duprex, Microbiology Today, November, 2011)

Editors and Affiliations

  • Novartis Vaccines & Diagnostics, Cambridge, USA

    Philip R. Dormitzer

  • Novartis Vaccines & Diagnostics, Inc., Cambridge, USA

    Christian W. Mandl

  • Novartis Vaccines & Diagnostics S.r.l., Siena, Italy

    Rino Rappuoli

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