Milestones in Drug Therapy

Twenty Years of G-CSF

Clinical and Nonclinical Discoveries

Editors: Molineux, Graham, Foote, MaryAnn, Arvedson, Tara (Eds.)

  • Many of the authors are the original investigators of recombinant human G-CSF
  • Key researchers provide their outlook for the next 20 years
  • Describes oncological and non-oncological applications
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eBook $229.00
price for USA (gross)
  • ISBN 978-3-0348-0218-5
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  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-0348-0217-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-3-0348-0804-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting.

This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.

Table of contents (25 chapters)

  • Hematopoiesis in 2010

    Morstyn, George

    Pages 3-13

  • Discovery of G-CSF and Early Clinical Studies

    Welte, Karl

    Pages 15-24

  • Mouse Models of G-CSF Signaling in Hematopoiesis

    Link, Daniel C

    Pages 25-40

  • The Clinical Pharmacology of Filgrastim and Pegfilgrastim

    Roskos, Lorin K.

    Pages 41-60

  • Structural Biology of G-CSF and Its Receptor

    Arvedson, Tara L. (et al.)

    Pages 61-82

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-0348-0218-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-0348-0217-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-3-0348-0804-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Twenty Years of G-CSF
Book Subtitle
Clinical and Nonclinical Discoveries
Editors
  • Graham Molineux
  • MaryAnn Foote
  • Tara Arvedson
Series Title
Milestones in Drug Therapy
Copyright
2012
Publisher
Springer Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-0218-5
DOI
10.1007/978-3-0348-0218-5
Hardcover ISBN
978-3-0348-0217-8
Softcover ISBN
978-3-0348-0804-0
Series ISSN
2296-6056
Edition Number
1
Number of Pages
XXII, 478
Topics