Progress in Inflammation Research

The Inflammasomes

Editors: Couillin, Isabelle, Pétrilli, Virginie, Martinon, Fabio (Eds.)

  • Overview on the current knowledge of inflammasome biology
  • Highlights the role of inflammasomes in health and disease
  • With contributions by leading international experts
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About this book

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

Table of contents (14 chapters)

  • Molecular Definition of Inflammasomes

    Pétrilli, Virginie (et al.)

    Pages 1-16

  • Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection

    Labbé, Katherine (et al.)

    Pages 17-36

  • Activation of the Inflammasome by Bacterial Pathogens

    Ulland, Tyler K. (et al.)

    Pages 37-50

  • The Role of Inflammasomes in Viral Infection

    Lupfer, Christopher R. (et al.)

    Pages 51-64

  • Inflammasome Activation in Response to Eukaryotic Pathogens

    Gross, Olaf (et al.)

    Pages 65-83

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-0348-0148-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-0348-0147-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-0348-0343-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
The Inflammasomes
Editors
  • Isabelle Couillin
  • Virginie Pétrilli
  • Fabio Martinon
Series Title
Progress in Inflammation Research
Copyright
2011
Publisher
Springer Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-0148-5
DOI
10.1007/978-3-0348-0148-5
Hardcover ISBN
978-3-0348-0147-8
Softcover ISBN
978-3-0348-0343-4
Edition Number
1
Number of Pages
XIV, 226
Topics