Experientia Supplementum

Galanin

Editors: Hökfelt, Tomas (Ed.)

  • Comprehensive collection of information on galaninergic functions and mechanisms
  • Explains how a new methodological approach can lead to the detection of a new substance class
  • Describes potential applications in drug development for a variety of conditions
  • Useful for basic neuroscientists and clinicians alike
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eBook $229.00
price for USA (gross)
  • ISBN 978-3-0346-0228-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.00
price for USA
  • ISBN 978-3-0346-0227-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $299.00
price for USA
  • ISBN 978-3-0348-0312-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

Table of contents (18 chapters)

  • Galanin: A Multitalented Neuropeptide

    Hökfelt, T. (et al.)

    Pages 1-5

  • Galanin, Galanin Receptors, and Drug Targets

    Mitsukawa, K. (et al.)

    Pages 7-23

  • Galanin Acts as a Trophic Factor to the Central and Peripheral Nervous Systems

    Hobson, S-A. (et al.)

    Pages 25-38

  • Galanin and Spinal Pain Mechanisms: Past, Present, and Future

    Xu, Xiao-Jun (et al.)

    Pages 39-50

  • Galanin Family of Peptides in Skin Function

    Bauer, J. W. (et al.)

    Pages 51-59

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-0346-0228-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.00
price for USA
  • ISBN 978-3-0346-0227-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $299.00
price for USA
  • ISBN 978-3-0348-0312-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Galanin
Editors
  • Tomas Hökfelt
Series Title
Experientia Supplementum
Series Volume
102
Copyright
2010
Publisher
Springer Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0346-0228-0
DOI
10.1007/978-3-0346-0228-0
Hardcover ISBN
978-3-0346-0227-3
Softcover ISBN
978-3-0348-0312-0
Series ISSN
1023-294X
Edition Number
1
Number of Pages
X, 286
Topics