Editors:
Focuses on the neuropsychopharmacology of GABA and its role in sleep and wakefulness
Presents neurochemical, electrophysiological, and neuropharmacological approaches to understand GABAergic mechanisms
Offers an overview of current approaches and medications
Features contributing authors who are leading experts in the field of sleep and neuropharmacology
Includes supplementary material: sn.pub/extras
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Table of contents (20 chapters)
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Front Matter
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Basic Physiology and Pharmacology
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Front Matter
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Sleep Science and Circuitry
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Front Matter
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Hypnotics
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Front Matter
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About this book
GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia.
The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.
Editors and Affiliations
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School of Medicine, Dept. Pharmacology & Therapeutics, Clinics Hospital Montevideo, Montevideo, Uruguay
Jaime M. Monti
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Somnogen, Inc., Toronto, Canada
Seithikurippu Ratnas Pandi-Perumal
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Institut für Pharmakologie und, Toxikologie, Universität Zürich, Zürich, Switzerland
Hanns Möhler
Bibliographic Information
Book Title: GABA and Sleep
Book Subtitle: Molecular, Functional and Clinical Aspects
Editors: Jaime M. Monti, Seithikurippu Ratnas Pandi-Perumal, Hanns Möhler
DOI: https://doi.org/10.1007/978-3-0346-0226-6
Publisher: Springer Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Basel AG 2010
Hardcover ISBN: 978-3-0346-0225-9Published: 30 September 2010
Softcover ISBN: 978-3-0348-0740-1Published: 23 September 2014
eBook ISBN: 978-3-0346-0226-6Published: 28 September 2010
Edition Number: 1
Number of Pages: XXIV, 486
Topics: Human Physiology