Milestones in Drug Therapy

Gene Therapy for Autoimmune and Inflammatory Diseases

Editors: Chernajovsky, Yuti, Robbins, Paul D. (Eds.)

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About this book

In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

Reviews

“The information is quite extensive and useful. Each chapter is well referenced. This monograph is highly specialized but is easily understandable. It is recommended for all researchers - both clinical and non-clinical, particularly those working in the fields of gene therapy, immunology, rheumatology, pharmacology and molecular medicine. It will also be a useful reference source for the libraries of all advanced academic centers and research institutions.” (S. S. Agarwal, Indian Journal of Medical Research, Vol. 135, April, 2012)

“This monograph contains new and valuable information regarding relevant topics ranging from disease entities to vectors and engineered cells. The authors, all of them international experts, take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long term genetic interventions. … The present volume is of an exceptional value for clinicians and scientists interested in introducing gene therapy into clinical use.” (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)


Table of contents (15 chapters)

  • Gene therapy for arthritis

    Apparailly, Florence (et al.)

    Pages 1-18

  • Gene therapy for the treatment of inflammatory bowel disease

    Ruffner, Melanie A. (et al.)

    Pages 19-37

  • Gene therapy for diabetes

    Noguchi, Hirofumi

    Pages 39-46

  • Gene therapy for cystic fibrosis lung disease

    Sumner-Jones, Stephanie G. (et al.)

    Pages 47-64

  • Gene therapy of multiple sclerosis

    Furlan, Roberto (et al.)

    Pages 65-78

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-0346-0165-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-0346-0164-1
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $259.00
price for USA
  • ISBN 978-3-0348-0306-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gene Therapy for Autoimmune and Inflammatory Diseases
Editors
  • Yuti Chernajovsky
  • Paul D. Robbins
Series Title
Milestones in Drug Therapy
Copyright
2010
Publisher
Springer Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-0346-0165-8
DOI
10.1007/978-3-0346-0165-8
Hardcover ISBN
978-3-0346-0164-1
Softcover ISBN
978-3-0348-0306-9
Series ISSN
2296-6056
Edition Number
1
Number of Pages
XI, 239
Topics