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Menstrual Cycle Related Disorders

Volume 7: Frontiers in Gynecological Endocrinology

  • Focuses on pathogenesis, clinics and therapeutics
  • Written by leading experts in the field
  • Provides a comprehensive overview from adolescence to menopause

Part of the book series: ISGE Series (ISGE)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-vi
  2. The Hypothalamic-Pituitary-Ovarian Axis and Regulation of the Menstrual Cycle

    • Frederick Naftolin, Ashraf Khafaga, Margaret Nachtigall
    Pages 1-13
  3. Hypothalamic Amenorrhea

    • Sarah L. Berga
    Pages 15-26
  4. Kisspeptin Role in Functional Hypothalamic Amenorrhea

    • Agnieszka Podfigurna, Adam Czyzyk, Anna Szeliga, Błażej Meczekalski
    Pages 27-42
  5. Polycystic Ovary Syndrome

    • Stavroula A. Paschou, Dimitrios G. Goulis, Basil C. Tarlatzis
    Pages 55-67
  6. Metabolism, Obesity, Thinness, and Reproduction

    • Alessia Prati, Antonella Napolitano, Giulia Despini, Alba Manzo, Martina Caroli, Alessandro D. Genazzani
    Pages 69-81
  7. Management of Adolescent Hyperandrogenism: Still a Challenge?

    • Charles Sultan, Laura Gaspari, Laurent Maïmoun, Nicolas Kalfa, Françoise Paris
    Pages 83-92
  8. Hormonally Related Headaches

    • Rossella E. Nappi, Silvia Martella, Grazia Sances, Manuela Piccinino, Roberta Rossini, Lara Tiranini et al.
    Pages 93-100
  9. Diagnosing Abnormal Uterine Bleeding: The Standard of Care Has Changed

    • Ashraf Khafaga, Steven R. Goldstein
    Pages 101-110
  10. Hormone Replacement Therapy in Premature Ovarian Insufficiency

    • Vincenzina Bruni, Francesca Pampaloni
    Pages 111-142
  11. Premature Ovarian Insufficiency: Practical Management Approaches

    • Sophia Tsiligiannis, Nick Panay, John C. Stevenson
    Pages 143-153
  12. Management of Transsexuality in an Outpatient Gynecologic Area

    • Iuliia Naumova, Camil Castelo-Branco
    Pages 155-166
  13. Regulation of Proliferation and Invasion in Endometriosis

    • N. Rohloff, M. Götte, L. Kiesel
    Pages 167-175
  14. Hormones and Inflammation: An Update on Endometriosis

    • Dora Pavone, Irene Turrini, Flavia Sorbi, Silvia Vannuccini, Tommaso Capezzuoli, Massimiliano Fambrini et al.
    Pages 177-192
  15. Selective Progesterone Receptor Modulators for Contraception with Added Health Benefits

    • Kristina Gemzell-Danielsson, Marielle E. Meurice
    Pages 217-223
  16. Back Matter

    Pages 225-234

About this book

This volume discusses menstrual cycle related disorders, which are a major concern from adolescence to menopause.  

Starting from hypothalamic pituitary gonadal axis regulation, it analyzes the characteristics and treatments of hypothalamic amenorrhea and eating disorders, as well as polycystic ovary and adolescent hyperandrogenism. It also examines the importance of body composition and physical performance. The book particularly focuses on the diagnosis of and therapies for hormone-related headaches, the management of trans sexuality in the gynecological outpatient area, dysfunctional uterine bleeding and premature ovarian insufficiency. Further, it analyzes the basic, clinical and therapeutic aspects of endometriosis, as well as the important opportunities that SPRMs (selective progesterone receptor modulators) offer in contraception and fibroid therapy.

This book is a useful tool for gynecologists, endocrinologists and general practitioners,and is a valuable resource for all physicians involved in women’s health.

Editors and Affiliations

  • Wake Forest SOM/WF Baptist Medical Center, Executive Director Women’s Health Services, Winston Salem, USA

    Sarah L. Berga

  • International Society of Gynecological Endocrinology, University of Pisa, Pisa, Italy

    Andrea R. Genazzani

  • Department of Obstetrics and Gynecology, New York University, New York, USA

    Frederick Naftolin

  • Department of Obstetrics and Gynaecology, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy

    Felice Petraglia

About the editors

Sarah L. Berga, MD became the Professor and Director of the Division of Reproductive Endocrinology and Infertility (REI) in the Department of Obstetrics and Gynecology at University of Utah Health in April 2018.  

Dr. Berga obtained her undergraduate and medical degrees from the University of Virginia and then completed a residency in Obstetrics and Gynecology at Harvard Medical School followed by a fellowship in REI at UCSD.  Prior faculty positions include Professor of Obstetrics, Gynecology and Reproductive Sciences and Psychiatry at the University of Pittsburgh Medical Center, Senior Scientist at Magee-Women’s Research Institute, and Medical Director of Magee-Women’s Clinical Research Center (1988-2003); Professor and Chair of Gynecology and Obstetrics at Emory University (2003-2010) with a secondary appointment in Psychiatry; and Chair of Obstetrics and Gynecology and Executive Director of Women’s Health at Wake Forest Baptist Medical Center (2011-2018).  

Her research explores neuroendocrine mechanisms mediating stress-induced reproductive compromise and the impact of hormones on brain health delineated by combining neuroimaging with characterization of hormonal and cognitive patterns.  She currently serves on the editorial boards of the Journal of Clinical Endocrinology and Metabolism (JCEM), Journal of Obstetrics and Gynecology of Canada (JOGC), American Journal of Obstetrics and Gynecology (AJOG), and Menopause.  She also serves as an Associate Editor for Human Reproduction Update (HRU).  Awards include the SGI Presidential Achievement Award and the Berthold Medal of the Deutsche Gesellschaft für Endokrinologie.  Past leadership positions include President of SGI (now Society for Reproductive Investigation) and Society of Humanism in Medicine and member of the Board of Directors of Emory Healthcare, University of Pittsburgh Physicians, and American Society of Reproductive Medicine (ASRM).  Shecurrently serves on the board of the International Society of Gynecologic Endocrinology and the Board of Trustees of Salem College, the first women’s college in America founded in 1772.  

Andrea R. Genazzani has been professor and Director of the Department of Obstetrics and Gynecology of the Universities of Cagliari, Modena and Pisa from 1980 to 2012. He is President of the International Society of Gynecological Endocrinology, President of the European Society of Gynecology, General Secretary of the International Academy of Human Reproduction, Chairman of the FIGO Working Group on Post Reproductive Health (FIGO-WGPRH), Fellow ad eundem of the Royal College of Obstetricians and Gynecologists, Fellow at the American College of Obstetricians and Gynecologists. Dr. Genazzani is Editor-in-Chief of Gynecological Endocrinology since 1987. He is author of more than 841 papers in peer reviewed journals and Editor of more than 51 books.


Frederick Naftolin is professor of Obstetrics and Gynecology and director of Reproductive Biology Research, Department of Obstetrics and Gynecology at New York University. His hospital appointments include being an attending physician in Obstetrics and Gynecology at University Hospital UCSD, at Boston Hospital For Women, and at the Royal Victoria Hospital, Montreal. He is a fellow of the American Gynecological and Obstetrical Society, an elected member of the International Academy of Human Reproduction, and member of the Pan American Health and Education Foundation Board of Trustees, and is on the Scientific Advisory Board of the Kronos Longevity Research Institute and the Executive Board of the International Menopause Society. Prof. Naftolin is also on the Editorial Boards of Current Women's Health Reviews, Climacteric, Early Pregnancy, Menopause, and the Journal of the Society for Gynecologic Investigation.

Felice Petraglia is the new head of the Maternal and Child Department and professor ofObstetrics and Gynecology at Careggi University Hospital, Florence, Italy. He is the former head of the Obstetrics and Gynecology at the University of Siena, Italy. Since 2004 he has been an adjunct professor at the Department of Obstetrics and Gynecology at University of Toronto, Canada.  He is a fellow ad eundem of the Royal College of Obstetricians and Gynecologists (RCOG), member of Steering Committee WHO Sexual and Reproductive Health Guideline Development Group and member of the Pontificial Academy for Life. Prof. Petraglia has served as President of the Society for Gynecologic Investigation. He was also a member of the Board and Committees of FIGO, ISGE, ESHRE and EBCOG and was a consultant to the Ministry of Health and Ministry of University in Italy.  He is editor-in-chief of Human Reproductive Update, and section head of Reproductive Endocrinology and Infertility at Faculty 1000 Medicine. He is a member of the Editorial Board of Reproductive Sciences, the Journal of Endometriosis and Pelvic Pain Disorders, and Gynecological Endocrinology

Bibliographic Information

  • Book Title: Menstrual Cycle Related Disorders

  • Book Subtitle: Volume 7: Frontiers in Gynecological Endocrinology

  • Editors: Sarah L. Berga, Andrea R. Genazzani, Frederick Naftolin, Felice Petraglia

  • Series Title: ISGE Series

  • DOI: https://doi.org/10.1007/978-3-030-14358-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: International Society of Gynecological Endocrinology 2019

  • Hardcover ISBN: 978-3-030-14357-2Published: 17 July 2019

  • Softcover ISBN: 978-3-030-14360-2Published: 15 August 2020

  • eBook ISBN: 978-3-030-14358-9Published: 02 July 2019

  • Series ISSN: 2197-8735

  • Series E-ISSN: 2197-8743

  • Edition Number: 1

  • Number of Pages: VI, 234

  • Number of Illustrations: 10 b/w illustrations, 33 illustrations in colour

  • Topics: Gynecology, Endocrinology

Buy it now

Buying options

eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 69.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access