Methods in Molecular Biology

Therapeutic Antibodies

Methods and Protocols

Editors: Dimitrov, Antony S. (Ed.)

  • Outlines the current state and future trends for therapeutic antibodies
  • Provides complete guidelines to discover and develop therapeutic antibodies, from antigen production to animal studies
  • Presents a modular approach with each part of the book tracing a stage of antibody discovery and preclinical development
  • Details the most recent protocols in antibody discovery and engineering, currently used by leading academic laboratories and biotechnology companies
  • Describes alternate approaches for antibody discovery and characterization
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eBook $149.00
price for USA (gross)
  • ISBN 978-1-59745-554-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-934115-92-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-62703-869-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

With revenues from the top five therapeutic antibodies accounting for a majority of the recent pharmaceutical sales, the research and development in the field has exploded over the past several years and is expected to grow with new emerging monoclonal antibodies like Numax, Lucentis, Actemra, and others. In Therapeutic Antibodies: Methods and Protocols, leading experts from academic laboratories and biotechnology companies present an extensive set of protocols for the discovery and development of therapeutic antibodies, featuring sections devoted to recombinant antigens, antibody libraries, antibody discovery, antibody engineering, and antibody preclinical development. Written in the highly successful Methods in Molecular Biology™ series format, the chapters contain brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls.

Comprehensive and cutting-edge, Therapeutic Antibodies: Methods and Protocols serves as a key resource for researchers and antibody engineers investigating and participating in this rapidly growing therapeutic market segment.

Reviews

From the reviews:

"This is an informative and practical handbook for those involved in the discovery and development of therapeutic antibodies. … Intended for those in the pharmaceutical industry or academia … and in the offices of those who direct projects which include this type of work. … This is a valuable addition to the libraries of those who perform day-to-day work in this field, or who manage projects involving therapeutic antibodies. … this is a valuable guide." (Frederick D. Coffman, Doody’s Review Service, June, 2009)


Table of contents (32 chapters)

  • Therapeutic Antibodies: Current State and Future Trends – Is a Paradigm Change Coming Soon?

    Dimitrov, Dimiter S. (et al.)

    Pages 1-27

  • Organizing, Exploring, and Analyzing Antibody Sequence Data: The Case for Relational-Database Managers

    Owens, John

    Pages 1-12

  • Preparation of Recombinant Viral Glycoproteins for Novel and Therapeutic Antibody Discovery

    Chan, Yee-Peng (et al.)

    Pages 31-58

  • Design of a Human Synthetic Combinatorial Library of Single-Chain Antibodies

    Nahary, Limor (et al.)

    Pages 61-80

  • Construction of a Human Antibody Domain (VH) Library

    Chen, Weizao (et al.)

    Pages 81-99

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-59745-554-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-934115-92-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-62703-869-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Therapeutic Antibodies
Book Subtitle
Methods and Protocols
Editors
  • Antony S. Dimitrov
Series Title
Methods in Molecular Biology
Series Volume
525
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-554-1
DOI
10.1007/978-1-59745-554-1
Hardcover ISBN
978-1-934115-92-3
Softcover ISBN
978-1-62703-869-0
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVIII, 585
Topics