Cancer Drug Discovery and Development

Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

Editors: Bonavida, Benjamin (Ed.)

  • The first volume to compile studies on tumor cell sensitization
  • Useful for students, scientists, clinicians and pharmaceutical companies
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Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59745-474-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-934115-29-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-928-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Cancer chemotherapy can be traced back to the 1940’s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.

Reviews

From the reviews: “This book introduces emerging strategies, potential signaling pathways and biomolecules as key targets to sensitize resistant cancers. … detailed information and data can be obtained from the references listed at the end of each chapter. This book helps chemists to enrich their biological insight, and biologists to acquire new chemical strategies in reversing cancer resistance. … the book is also recommended to students in these fields. For scientists in industry and academia, and clinicians, this book provides an overview of current approaches … .” (Yoshihiko Kotake, ChemMedChem, Vol. 4, 2009)

Table of contents (22 chapters)

  • Sensitization of Epithelial Cancer Cells with Human Monoclonal Antibodies

    Vollmers, H. Peter (et al.)

    Pages 3-11

  • Targeting the Transferrin Receptor to Overcome Resistance to Anti-Cancer Agents

    Daniels, Tracy R. (et al.)

    Pages 13-27

  • Chemo-Immunosensitization of Resistant B-NHL as a Result of Rituximab (anti-CD20 mAb)-Mediated Inhibition of Cell Survival Signaling Pathways

    Bonavida, Benjamin (et al.)

    Pages 29-39

  • Agents that Regulate DR5 and Sensitivity to TRAIL

    Yoshida, Tatsushi (et al.)

    Pages 41-49

  • Proteasome Inhibition: Potential for Sensitization of Immune Effector Mechanisms in Cancer

    Motarjemi, Milad (et al.)

    Pages 51-60

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59745-474-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-934115-29-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-928-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy
Editors
  • Benjamin Bonavida
Series Title
Cancer Drug Discovery and Development
Copyright
2008
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-474-2
DOI
10.1007/978-1-59745-474-2
Hardcover ISBN
978-1-934115-29-9
Softcover ISBN
978-1-61737-928-4
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XXII, 420
Topics