Clinical Trials

Clinical Trials in Rheumatoid Arthritis and Osteoarthritis

Editors: Reid, David, Miller, Colin (Eds.)

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eBook $119.00
price for USA (gross)
  • ISBN 978-1-84628-742-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA
  • ISBN 978-1-85233-874-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Designed to be a practical handbook on clinical trial management in these key therapeutic areas, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed at principal investigators pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases.

 

In the last several years a new classes of biologic agents have emerged and changed the treatment paradigm for patients, not only with classically defined rheumatoid arthritis, but also with other related diseases such as ankylosing spondylitis and psoriatic arthritis.  Furthermore, osteoarthritis is a major disease state that is often treated by the rheumatologist, but is one where patient management programs are currently limited with a need for new therapeutic approaches.

 

In both inflammatory and non-inflammatory arthritic conditions, clinical trials have become both large and complex due to the nature of the diseases, with ever-challenging new surrogate end-points being employed.

 

Topics covered in this title will therefore include study design, clinical endpoints, technical issues, data collection, use of centralized medical image reading facilities and biochemical marker laboratories, as well as data analysis and future therapies.  This book takes the user through the process step-by-step from start to finish, also providing a background on the regulatory guidelines, ethical implications, endpoints, and current therapies.

Reviews

This unique addition to the field of rheumatology focuses on the elements critical for the design and management of clinical trials in rheumatoid arthritis and osteoarthritis...The authors do an excellent job of breaking down how prominent clinical trials designed endpoints, collected and analyzed data, and avoided regulatory hurdles so readers can initiate trials of their own.  This is a worthwhile read for those interested in performing clinical trials in either disease...For those without any formal training in clinical research, this book does the trick.

-Doody's, reviewed by Alfred H. Kim, PhD (Washington University Medical Center)


Table of contents (18 chapters)

  • Introduction

    Reid, David M. (et al.)

    Pages 1-3

  • Historical and Current Perspectives on Management of Osteoarthritis and Rheumatoid Arthritis

    Dubey, Shirish (et al.)

    Pages 5-36

  • Development of Biological Therapies for Inflammatory Arthritis

    Basu, Neil

    Pages 37-49

  • Study Design and End Points for Rheumatoid Arthritis Trials

    Geusens, Pieter (et al.)

    Pages 51-67

  • Study Design and End Points in Ankylosing Spondylitis Clinical Trials

    Heijde, Dèsirèe

    Pages 69-79

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-1-84628-742-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA
  • ISBN 978-1-85233-874-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Clinical Trials in Rheumatoid Arthritis and Osteoarthritis
Editors
  • David Reid
  • Colin Miller
Series Title
Clinical Trials
Copyright
2008
Publisher
Springer-Verlag London
Copyright Holder
Springer-Verlag London
eBook ISBN
978-1-84628-742-8
DOI
10.1007/978-1-84628-742-8
Softcover ISBN
978-1-85233-874-9
Edition Number
1
Number of Pages
VIII, 328
Number of Illustrations and Tables
30 b/w illustrations, 24 illustrations in colour
Topics