Topics in Bone Biology

Bone and Osteoarthritis

Editors: Bronner, Felix, Farach-Carson, Mary C. (Eds.)

  • Offers a unique combination of information on the relationship of bone to the development of osteoarthritis
  • Covers the pathophysiology of joints
  • Updates current knowledge of signaling molecules, mechanisms of cartilage destruction, the role of bone in osteoarthritis and more
  • Offers insights into anabolic mediators of cartilage healing, novel therapeutics and pathogenesis of osteoarthritis
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eBook $309.00
price for USA (gross)
  • ISBN 978-1-84628-701-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $399.00
price for USA
  • ISBN 978-1-84628-513-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $399.00
price for USA
  • ISBN 978-1-84996-617-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease.

A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis.

Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury.

Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology.

This book, intended for clinicians, researchers and students, provides information that will orient the novice and update the specialist. No other book treats the relationship of bone to osteoarthritis in similar fashion or provides a comparable underpinning of joint pathophysiology.

About the authors

Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA. In this fourth volume, the Series Editors are joined by a co-editor with special expertise in the volume topic, Dr Richard F. Loeser, MD, the Robert S. Katz, MD - Joan and Paul Rubschlager Presidential Professor of Osteoarthritis Research in the Department of Internal Medicine, Section of Rheumatology with a conjoint appointment in the Department of Biochemistry, Rush University, Chicago, IL, USA.

Table of contents (11 chapters)

  • The Pathogenesis of Osteoarthritis

    Roach, Helmtrud I. (et al.)

    Pages 1-18

  • The Role of Bone in the Development of Osteoarthritis

    Lajeunesse, Daniel (et al.)

    Pages 19-39

  • Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage

    Goldring, Mary B.

    Pages 41-63

  • The Synovium and Its Role in Osteoarthritis

    Blom, Arjen B. (et al.)

    Pages 65-79

  • Cartilage Matrix Destruction

    HeinegÄrd, Dick

    Pages 81-95

Buy this book

eBook $309.00
price for USA (gross)
  • ISBN 978-1-84628-701-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $399.00
price for USA
  • ISBN 978-1-84628-513-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $399.00
price for USA
  • ISBN 978-1-84996-617-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Bone and Osteoarthritis
Editors
  • Felix Bronner
  • Mary C. Farach-Carson
Series Title
Topics in Bone Biology
Series Volume
4
Copyright
2007
Publisher
Springer-Verlag London
Copyright Holder
Springer-Verlag London
eBook ISBN
978-1-84628-701-5
DOI
10.1007/978-1-84628-701-5
Hardcover ISBN
978-1-84628-513-4
Softcover ISBN
978-1-84996-617-7
Series ISSN
2199-2436
Edition Number
1
Number of Pages
XIV, 218
Number of Illustrations and Tables
19 b/w illustrations, 25 illustrations in colour
Topics