Methods in Molecular Biology

Enzyme Kinetics in Drug Metabolism

Fundamentals and Applications

Editors: Nagar, Swati, Argikar, Upendra, Tweedie, Donald (Eds.)

  • Includes clear explanations of fundamentals for correct application
  • Contains key notes, experiences and implementation advice from the experts
  • Covers relevant and current topics including Drug Metabolizing Enzymes and Transporters
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eBook $119.00
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  • ISBN 978-1-62703-758-7
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Hardcover $159.00
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Softcover $159.00
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About this book

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.

Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.   

Table of contents (24 chapters)

  • Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications

    Nagar, Swati (et al.)

    Pages 1-6

  • Fundamentals of Enzyme Kinetics

    Seibert, Eleanore (et al.)

    Pages 9-22

  • Different Enzyme Kinetic Models

    Seibert, Eleanore (et al.)

    Pages 23-35

  • Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance

    Ring, Barbara (et al.)

    Pages 37-56

  • Irreversible Enzyme Inhibition Kinetics and Drug–Drug Interactions

    Mohutsky, Michael (et al.)

    Pages 57-91

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-1-62703-758-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-1-62703-757-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • ISBN 978-1-4939-6046-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Enzyme Kinetics in Drug Metabolism
Book Subtitle
Fundamentals and Applications
Editors
  • Swati Nagar
  • Upendra Argikar
  • Donald Tweedie
Series Title
Methods in Molecular Biology
Series Volume
1113
Copyright
2014
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-62703-758-7
DOI
10.1007/978-1-62703-758-7
Hardcover ISBN
978-1-62703-757-0
Softcover ISBN
978-1-4939-6046-0
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVIII, 538
Number of Illustrations and Tables
98 b/w illustrations, 36 illustrations in colour
Topics