Methods in Pharmacology and Toxicology

Optimization in Drug Discovery

In Vitro Methods

Editors: Caldwell, Gary W., Yan, Zhengyin (Eds.)

  • Provides updated variations on assays as well as numerous new protocols for drug discovery optimization
  • Features readily reproducible methods and protocols that are lab-tested and successful
  • Includes expert tips and key implementation advice
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eBook $119.00
price for USA (gross)
  • ISBN 978-1-62703-742-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-1-62703-741-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • ISBN 978-1-4939-6070-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

Table of contents (34 chapters)

  • Small Molecule Formulation Screening Strategies in Drug Discovery

    Caldwell, Gary W. (et al.)

    Pages 1-20

  • Assessment of Drug Plasma Protein Binding in Drug Discovery

    Kalamaridis, Dennis (et al.)

    Pages 21-37

  • Drug Partition in Red Blood Cells

    Kalamaridis, Dennis (et al.)

    Pages 39-47

  • Permeability Assessment Using 5-day Cultured Caco-2 Cell Monolayers

    Caldwell, Gary W. (et al.)

    Pages 49-76

  • In Situ Single Pass Perfused Rat Intestinal Model

    Markowska, Maria (et al.)

    Pages 77-86

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-1-62703-742-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-1-62703-741-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • ISBN 978-1-4939-6070-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Optimization in Drug Discovery
Book Subtitle
In Vitro Methods
Editors
  • Gary W. Caldwell
  • Zhengyin Yan
Series Title
Methods in Pharmacology and Toxicology
Copyright
2014
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-62703-742-6
DOI
10.1007/978-1-62703-742-6
Hardcover ISBN
978-1-62703-741-9
Softcover ISBN
978-1-4939-6070-5
Series ISSN
1557-2153
Edition Number
2
Number of Pages
XVII, 597
Number of Illustrations and Tables
64 b/w illustrations, 49 illustrations in colour
Topics