Oxidative Stress in Applied Basic Research and Clinical Practice

Studies on Alzheimer's Disease

Editors: Praticὸ, Domenico, Mecocci, Patrizia (Eds.)

  • Reviews the basic science and clinical knowledge of the role of oxidative stress in the pathology of Alzheimer’s disease
  • Describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment of Alzheimer's disease
  • Provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents
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eBook $159.00
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  • ISBN 978-1-62703-598-9
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  • Immediate eBook download after purchase
Hardcover $209.00
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  • ISBN 978-1-62703-597-2
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  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
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  • ISBN 978-1-4939-6034-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress,” in the pathology of Alzheimer’s disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer’s Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimer’s Disease.

About the authors

Dr. Domenico Praticò received his M.D. from the University of Rome “La Sapienza,” School of Medicine where he completed a residency program in Internal Medicine. After receiving a European Research Award fellowship, he spent two years of post-doctoral training at the University of Dublin as a fellow in the Center for Cardiovascular Science. Next, he joined the University of Pennsylvania as Research Associate, where later he was promoted to Assistant Professor. He is currently Professor of Pharmacology, Microbiology and Immunology and member of the Center for Translational Medicine at Temple University. His main research interest is oxidative biology with a particular focus on bioactive lipids, their metabolic pathways, and their role as biological mediators of cellular and molecular events in the pathogenesis of human diseases, including neurodegenerative and cardiovascular diseases. Dr. Pratico has published more than 195 papers in peer-reviewed scientific journals, and has received many awards for his research accomplishments including the Irvine H. Page Award, Neurosciences Education and Research Award, The Zenith Award from the Alzheimer’s Association, and the Dorothy Dillon Eweson Lectureship.

Dr. Patrizia Mecocci received her MD from the University of Perugia, School of Medicine where she completed a residency program in Geriatrics. She also earned a PhD in Biology and Physiopathology of Aging at the University of Modena (Italy). After receiving a grant from the Italian National Research Council (CNR),  she spent three years as research fellow first  at the Department of Psychiatry and Neurochemistry at the University of Lund (Sweden) and then at the Department of Neurology, MGH-Harvard Medical School in Boston. She then started the academic career at the University of Perugia where she is now Full Professor in Gerontology and Geriatrics and Director of the Geriatric Clinic.  Dr. Mecocci’s research is mainly devoted to clinical geriatrics, with a specific interest on brain aging and dementia and on age-related biological modifications,  with a particular focus on the role of oxidants and antioxidants in neurodegenerative and cardiovascular diseases.  She has been PI or co-investigator in research projects funded by the European Commission and by the Italian Ministry of Research. She is author of more than 180 papers in peer-reviewed scientific journals and 30 books and book chapters.

Table of contents (16 chapters)

  • Oxidative Stress: Impact in Neuroscience Research

    Sies, Helmut

    Pages 3-7

  • Oxidative Stress and Alzheimer’s Disease

    Castellani, Rudy J. (et al.)

    Pages 9-13

  • Inflammation and Oxidation: A Link in Alzheimer’s Disease Pathogenesis

    Hensley, Kenneth

    Pages 15-24

  • GAPDH: β-Amyloid Mediated Iron Accumulation in Alzheimer’s Disease: A New Paradigm for Oxidative Stress Induction in Neurodegenerative Disorders

    Sirover, Michael A.

    Pages 25-40

  • Aβ in Mitochondria—One Piece in the Alzheimer’s Disease Puzzle

    Ankarcrona, Maria

    Pages 41-53

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-62703-598-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-62703-597-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-6034-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Studies on Alzheimer's Disease
Editors
  • Domenico Praticὸ
  • Patrizia Mecocci
Series Title
Oxidative Stress in Applied Basic Research and Clinical Practice
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-62703-598-9
DOI
10.1007/978-1-62703-598-9
Hardcover ISBN
978-1-62703-597-2
Softcover ISBN
978-1-4939-6034-7
Series ISSN
2197-7224
Edition Number
1
Number of Pages
XI, 236
Number of Illustrations and Tables
5 b/w illustrations, 29 illustrations in colour
Topics