Methods in Molecular Biology

Phosphatase Modulators

Editors: Millán, José Luis (Ed.)

  • Serves as a "how to" manual for the initiation of drug discovery efforts
  • Provides step-by-step detail essential for reproducible results
  • Contains key tips and implementation advice from the experts
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eBook $109.00
price for USA (gross)
  • ISBN 978-1-62703-562-0
  • Digitally watermarked, DRM-free
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-62703-561-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4939-6031-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases.  Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results.

 

Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.

Table of contents (17 chapters)

  • Chemical Probe Development Versus Drug Development

    Jackson, Michael R.

    Pages 1-6

  • Phosphatase High-Throughput Screening Assay Design and Selection

    Sergienko, Eduard A.

    Pages 7-25

  • Multisystemic Functions of Alkaline Phosphatases

    Buchet, René (et al.)

    Pages 27-51

  • Robotic Implementation of Assays: Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study

    Chung, Thomas D. Y.

    Pages 53-84

  • Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP): From Hits to Leads

    Teriete, Peter (et al.)

    Pages 85-101

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-62703-562-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-62703-561-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4939-6031-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Phosphatase Modulators
Editors
  • José Luis Millán
Series Title
Methods in Molecular Biology
Series Volume
1053
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-62703-562-0
DOI
10.1007/978-1-62703-562-0
Hardcover ISBN
978-1-62703-561-3
Softcover ISBN
978-1-4939-6031-6
Series ISSN
1064-3745
Edition Number
1
Number of Pages
X, 315
Number of Illustrations and Tables
30 b/w illustrations, 45 illustrations in colour
Topics