Methods in Molecular Biology

Chemokines

Methods and Protocols

Editors: Cardona, Astrid E., Ubogu, Eroboghene E. (Eds.)

  • Features experimental models and state of the art protocols
  • Delineates chemokine/chemokine receptor function and their applications in health and disease
  • Includes key tips and expert implementation advice to ensure successful results
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eBook $109.00
price for USA (gross)
  • ISBN 978-1-62703-426-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-62703-425-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4939-6005-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Chemokines constitute a large family of structurally similar cytokines that contain a signature of conserved cysteine residues joined by disulfide bridges.  Binding of chemokines to specific G protein-coupled receptors followed by downstream signaling defines their biological function.  Initially, chemoattraction was the key function linked to chemokines/chemokine receptors; however, in recent years, it has become clear that chemokine ligand-receptor interactions can also modulate cellular activation, survival, and proliferation, among other functions in homeostatic and diseased states.  Importantly, major advances in our understanding of chemokine biology have led to chemokine receptors becoming specific therapeutic targets with great potential.  In Chemokines: Methods and Protocols, expert researchers provide practical information regarding experimental models and state of the art protocols used to delineate chemokine/chemokine receptor function and their applications in health and disease.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Practical and easy to use, Chemokines: Methods and Protocols aims to reveal key protocols of functional and descriptive chemokine ligand/receptor assays that will be of practical significance to graduate students, post-doctoral fellows, trainees, and researchers in academia and industry.

Table of contents (15 chapters)

  • The Fine Balance of Chemokines During Disease: Trafficking, Inflammation, and Homeostasis

    Cardona, Sandra M. (et al.)

    Pages 1-16

  • Chemokine-Dependent Signaling Pathways in the Peripheral Nervous System

    Ubogu, Eroboghene E.

    Pages 17-30

  • Multispectral Imaging and Automated Laser Capture Microdissection of Human Cortical Neurons: A Quantitative Study of CXCR4 Expression

    Pitcher, Jonathan (et al.)

    Pages 31-48

  • Chemokine Receptors and Neural Stem Cells

    Li, Meizhang

    Pages 49-55

  • Chemokine Receptor Interactions with Virus-Like Particles

    Buonaguro, Luigi (et al.)

    Pages 57-66

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-62703-426-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-62703-425-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4939-6005-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chemokines
Book Subtitle
Methods and Protocols
Editors
  • Astrid E. Cardona
  • Eroboghene E. Ubogu
Series Title
Methods in Molecular Biology
Series Volume
1013
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-62703-426-5
DOI
10.1007/978-1-62703-426-5
Hardcover ISBN
978-1-62703-425-8
Softcover ISBN
978-1-4939-6005-7
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 238
Number of Illustrations and Tables
18 b/w illustrations, 19 illustrations in colour
Topics