Methods in Molecular Biology

Trinucleotide Repeat Protocols

Editors: Kohwi, Yoshinori, McMurray, Cynthia T. (Eds.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
see more benefits

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-62703-411-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.00
price for USA
  • ISBN 978-1-62703-410-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover n/a
  • ISBN 978-1-4939-5971-6
  • Free shipping for individuals worldwide
About this book

Two decades have passed since trinucleotide repeat expansion was first discovered in genes responsible for certain neurological diseases. Since then, new technologies have developed and innovative concepts have emerged, which may prove useful in devising therapeutic approaches to neurological diseases. Divided into six convenient sections, Trinucleotide Repeat Protocols, Second Edition covers a wide range of topics such as an overview of trinucleotide repeat diseases, synaptic plasticity, embryonic stem (ES) cell-related protocols with a focus on HD, RNA-related protocols, and analysis of epigenetic modification in fragile X syndrome.  This edition focuses not only on direct analysis of trinucleotide repeat diseases but also on alternative approaches for the analysis of trinucleotide repeat diseases, with the hope that this will result in a better understanding of the mechanisms and future therapeutic prospects for treatment of these diseases. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible, Trinucleotide Repeat Protocols, Second Edition seeks to serve researchers with its thorough methodologies on this expanding field.

Table of contents (18 chapters)

  • A Brief History of Triplet Repeat Diseases

    Budworth, Helen (et al.)

    Pages 3-17

  • Huntington’s Disease and Cell Therapies: Past, Present, and Future

    Antoniades, Chrystalina A. (et al.)

    Pages 19-32

  • Transcranial Two-Photon Imaging of Synaptic Structures in the Cortex of Awake Head-Restrained Mice

    Yang, Guang (et al.)

    Pages 35-43

  • In Vivo Imaging of Synapse Plasticity in the Mouse Motor Cortex

    Zuo, Yi (et al.)

    Pages 45-57

  • Pluripotent Hybrid Stem Cells from Transgenic Huntington’s Disease Monkey

    Laowtammathron, Chuti (et al.)

    Pages 61-77

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-62703-411-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.00
price for USA
  • ISBN 978-1-62703-410-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover n/a
  • ISBN 978-1-4939-5971-6
  • Free shipping for individuals worldwide
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Trinucleotide Repeat Protocols
Editors
  • Yoshinori Kohwi
  • Cynthia T. McMurray
Series Title
Methods in Molecular Biology
Series Volume
1010
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-62703-411-1
DOI
10.1007/978-1-62703-411-1
Hardcover ISBN
978-1-62703-410-4
Softcover ISBN
978-1-4939-5971-6
Series ISSN
1064-3745
Edition Number
2
Number of Pages
XIII, 296
Number of Illustrations and Tables
40 b/w illustrations, 24 illustrations in colour
Topics