Methods in Molecular Biology

In Silico Models for Drug Discovery

Editors: Kortagere, Sandhya (Ed.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $109.00
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  • ISBN 978-1-62703-342-8
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About this book

Infectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide. Although new technologies have improved diagnosis of infectious diseases, the efficacy of all known current anti-infective agents is threatened by the spread of drug-resistant forms of the pathogens. Hence, there remains an urgent need to develop anti-infective agents that target drug-resistant pathogens. In Silico Models for Drug Discovery presents a comprehensive look at the role in silico models play in understanding infectious diseases and in developing novel therapeutics to treat them. Written by leading experts in the field, chapters cover topics such as techniques to derive novel antimicrobial targets, methods of interpreting polypharmacology-based drug target networks, and molecular dynamics techniques used to compute binding energies of drugs to their target proteins, to name a few. Written in the successful Methods in Molecular Biology™ series or in review article format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible, In Silico Models for Drug Discovery seeks to serve both professionals and novices involved in the study and treatment of infectious diseases.

Table of contents (16 chapters)

  • Virtual Screening in Drug Design

    Lill, Markus

    Pages 1-12

  • In Silico Systems Biology Approaches for the Identification of Antimicrobial Targets

    Sarker, Malabika (et al.)

    Pages 13-30

  • Genome Comparisons as a Tool for Antimicrobial Target Discovery

    Sun, Hong (et al.)

    Pages 31-38

  • In Silico Models for Drug Resistance

    Fatumo, Segun (et al.)

    Pages 39-65

  • An In Silico Model for Interpreting Polypharmacology in Drug–Target Networks

    Takigawa, Ichigaku (et al.)

    Pages 67-80

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-62703-342-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-62703-341-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
In Silico Models for Drug Discovery
Editors
  • Sandhya Kortagere
Series Title
Methods in Molecular Biology
Series Volume
993
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-62703-342-8
DOI
10.1007/978-1-62703-342-8
Hardcover ISBN
978-1-62703-341-1
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 265
Topics