Methods in Molecular Biology

Target Identification and Validation in Drug Discovery

Methods and Protocols

Editors: Moll, Jurgen, Colombo, Riccardo (Eds.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-62703-311-4
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Hardcover $169.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-62703-310-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4939-6278-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate. In Target Identification and Validation in Drug Discovery: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to identify and validate new target. These include methods and approaches covering biochemical, cell based, in vivo models and translational methods. Chapters also include selected case reports that demonstrate the integration of these technologies to real life experiences and to demonstrate the multiple use of more than one technology to increase knowledge on a specific target. These Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

 

Thorough and intuitive, Target Identification and Validation in Drug Discovery: Methods and Protocols contains a comprehensive list of essential methods and clear protocols to follow.

Table of contents (22 chapters)

  • The Path to Oncology Drug Target Validation: An Industry Perspective

    Cortés-Cros, Marta (et al.)

    Pages 3-13

  • Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity

    Ulrich, Henning (et al.)

    Pages 17-39

  • The Design and Structure–Functional Properties of DNA-Based Immunomodulatory Sequences

    Kuznetsov, Nikolai V.

    Pages 41-56

  • siRNA Design Principles and Off-Target Effects

    Petri, Sebastian (et al.)

    Pages 59-71

  • Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides

    Liang, Wanling (et al.)

    Pages 73-87

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-62703-311-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-62703-310-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4939-6278-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Target Identification and Validation in Drug Discovery
Book Subtitle
Methods and Protocols
Editors
  • Jurgen Moll
  • Riccardo Colombo
Series Title
Methods in Molecular Biology
Series Volume
986
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
Distribution Rights
Distribution rights for India: Mehul Book Sales, Mumbai, India
eBook ISBN
978-1-62703-311-4
DOI
10.1007/978-1-62703-311-4
Hardcover ISBN
978-1-62703-310-7
Softcover ISBN
978-1-4939-6278-5
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XV, 371
Topics