Methods in Molecular Biology

Tissue-Protective Cytokines

Methods and Protocols

Editors: Ghezzi, Pietro, Cerami, Anthony (Eds.)

  • Covers many aspects of the tissue-protective actions of erythropoietin (EPO) and other cytokines
  • Collects methods of models where cytokine molecules can be characterized
  • Presents notes on troubleshooting and avoiding pitfalls
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-62703-308-4
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Hardcover $169.00
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  • ISBN 978-1-62703-307-7
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About this book

While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines.

 In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs.

 

Table of contents (19 chapters)

  • Erythropoietin and Engineered Innate Repair Activators

    Brines, Michael (et al.)

    Pages 1-11

  • Epo and Non-hematopoietic Cells: What Do We Know?

    Ogunshola, Omolara O. (et al.)

    Pages 13-41

  • Tissue-Protective Cytokines: Structure and Evolution

    Ghezzi, Pietro (et al.)

    Pages 43-58

  • The Regenerative Activity of Interleukin-6

    Galun, Eithan (et al.)

    Pages 59-77

  • Brain Ischemic Injury in Rodents: The Protective Effect of EPO

    Letourneur, Annelise (et al.)

    Pages 79-101

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-62703-308-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-62703-307-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tissue-Protective Cytokines
Book Subtitle
Methods and Protocols
Editors
  • Pietro Ghezzi
  • Anthony Cerami
Series Title
Methods in Molecular Biology
Series Volume
982
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-62703-308-4
DOI
10.1007/978-1-62703-308-4
Hardcover ISBN
978-1-62703-307-7
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 328
Topics