Stem Cell Biology and Regenerative Medicine

Mitochondrial DNA, Mitochondria, Disease and Stem Cells

Editors: St. John, Justin C. (Ed.)

  • Cutting-edge research
  • Leading scientists and researchers as contributors comprehensive coverage of a hot topic
  • Describes processes of mitochondrial biogenesis and mitochondrial DNA replication as well as pluripotency and differentiation
see more benefits

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-62703-101-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-62703-100-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-62703-867-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

About the authors

Professor Justin St. John was awarded his PhD in 1999. In 2000, he was awarded a Mellon Fellowship at the Oregon National Primate Research Center, Oregon, USA. His achievements as an early career scientist led to his rapid promotion to the position of Professor at the University of Warwick (2007). Whilst in the UK, he was funded by the Medical Research Council and received an Endeavour Fellowship to undertake a period of research at Monash Institute of Medical Research where he has been Director of the Centre for Reproduction and Development and a Professor in the Faculty of Nursing, Medicine and Health Sciences at Monash University since November 2009. His research focuses on developing and using specific model systems to understand how mitochondrial DNA is transmitted and replicated. He was the first to demonstrate that sperm mitochondrial DNA could persist in the late stage embryo and thus be transmitted; describe mitochondrial DNA replication events in undifferentiated and differentiating embryonic stem cells; and demonstrate why donor cell mitochondrial DNA is transmitted to embryos and offspring following somatic cell nuclear transfer. He is using these outcomes to develop mini-pig models of mitochondrial DNA disease and reproductive strategies to prevent the transmission of mutant mitochondrial DNA from one generation to the next. He has published in The Lancet, Nature Chemical Biology, Nature Cell Biology, Stem Cells, Journal of Cell Science, and Genetics.

Table of contents (7 chapters)

  • Clinical Approach to the Diagnosis of Mitochondrial Disease

    Thyagarajan, Dominic

    Pages 1-23

  • Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease

    McKenzie, Matthew

    Pages 25-47

  • Embryonic Stem Cells: A Signalling Perspective

    Stavridis, Marios P.

    Pages 49-68

  • From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) a Mitochondrial Odyssey

    Ramalho-Santos, João (et al.)

    Pages 69-86

  • From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases

    Facucho-Oliveira, João (et al.)

    Pages 87-118

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-62703-101-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-62703-100-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-62703-867-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Mitochondrial DNA, Mitochondria, Disease and Stem Cells
Editors
  • Justin C. St. John
Series Title
Stem Cell Biology and Regenerative Medicine
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-62703-101-1
DOI
10.1007/978-1-62703-101-1
Hardcover ISBN
978-1-62703-100-4
Softcover ISBN
978-1-62703-867-6
Series ISSN
2196-8985
Edition Number
1
Number of Pages
X, 190
Topics