Methods in Molecular Biology

Therapeutic Proteins

Methods and Protocols

Editors: Voynov, Vladimir, Caravella, Justin A. (Eds.)

  • Presents detailed methods with added emphasis on therapeutic protein discovery 
  • Emphasizes new, cutting-edge technologies
  • Features key tips and valuable implementation advice to ensure successful results
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-61779-921-1
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  • Immediate eBook download after purchase
Hardcover $169.00
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  • ISBN 978-1-61779-920-4
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About this book

After the identification of a potential protein drug, the next critical step is the production of sufficient authentic material for testing, characterization, and clinical trials, which, when successful, leads to the need for robust methodologies for large-scale production, purification, characterization, viral inactivation, and continued testing of the final protein product.  Building on the valuable first edition, Therapeutic Proteins: Methods and Protocols, Second Edition aims to cover each of these key aspects of protein drug production through the contributions of authors from highly esteemed industrial and academic institutions around the world.  Emphasizing the newest developments in the field, this second edition also includes additional emphasis on discovery, including new display and screening methods as well as the design and engineering of new types of therapeutic proteins.  There is also discussion of computational and bioinformatics methods, and chapters on safety aspects of therapeutic protein development.  Written in the highly successful Methods in Molecular Biology™ format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Fully updated and practical, Therapeutic Proteins: Methods and Protocols, Second Edition provides an essential resource to all scientists working in the field of therapeutic proteins.

Table of contents (29 chapters)

  • Therapeutic Proteins

    Dimitrov, Dimiter S.

    Pages 1-26

  • Synthetic Antibody Libraries

    Nelson, Bryce (et al.)

    Pages 27-41

  • The Construction of “Phylomer” Peptide Libraries as a Rich Source of Potent Inhibitors of Protein/Protein Interactions

    Milech, Nadia (et al.)

    Pages 43-60

  • Ribosome Display and Screening for Protein Therapeutics

    Kastelic, Damjana (et al.)

    Pages 61-72

  • Yeast Display of Engineered Antibody Domains

    Zhao, Qi (et al.)

    Pages 73-84

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-61779-921-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-61779-920-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Therapeutic Proteins
Book Subtitle
Methods and Protocols
Editors
  • Vladimir Voynov
  • Justin A. Caravella
Series Title
Methods in Molecular Biology
Series Volume
899
Copyright
2012
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61779-921-1
DOI
10.1007/978-1-61779-921-1
Hardcover ISBN
978-1-61779-920-4
Series ISSN
1064-3745
Edition Number
2
Number of Pages
XI, 502
Topics