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Methods in Molecular Biology

Immunogenetics

Methods and Applications in Clinical Practice

Editors: Christiansen, Frank T., Tait, Brian D. (Eds.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $139.00
price for USA (gross)
  • ISBN 978-1-61779-842-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-1-61779-841-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells. They are also the major histocompatibility barriers to transplantation, which is the clinical paradigm of the self versus non self concept. It is now recognized that this diverse range of gene systems involved in the control of the immune response have been shown to be important in many aspects of clinical practice. As a result many new molecular and cellular methods have been developed for identifying these genes and their polymorphisms, and immunogenetic laboratories specializing in these methods have developed to support transplantation and other clinical programs. Immunogenetics: Methods and Applications in Clinical Practice focuses on methods for human clinical practice. The emphasis rests on those assays which are of established or potential clinical utility and are likely to be included in the repertoire of tests provided by a routine diagnostic and service laboratory. This volume also contains several review chapters of the MHC complex, the KIR complex, the human immunoglobulin allotypes, as well as reviews of the methods for the detection of alloreactive NK cells and the detection of HLA antibodies by solid phase assays.  Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible, Immunogenetics: Methods and Applications in Clinical Practice seeks to serve both the immunogenetics community  and the wider scientific community with a collection of detailed information and helpful tips attained by many years of experience in the field.

Reviews

From the reviews:

“This book is a comprehensive volume covering a wide-range of topics related to HLA in the clinical setting. … this book is an extremely useful reference for those working in the field of transplantation, or with an interest in the clinical applications of HLA. The introductory chapters to various topics are clear and provide a good amount of detail and are well referenced for those who wish to read further on the subject.” (Vivien Hanson, Immunology News, February, 2013)

Table of contents (34 chapters)

  • The Major Histocompatibility Complex: A Paradigm for Studies of the Human Genome

    Allcock, Richard J. N.

    Pages 1-7

  • HLA Typing by SSO and SSP Methods

    Dunckley, Heather

    Pages 9-25

  • Methods for Diagnostic HLA Typing in Disease Association and Drug Hypersensitivity

    Varney, Michael D. (et al.)

    Pages 27-46

  • HLA Typing Using Bead-Based Methods

    Trajanoski, Daniel (et al.)

    Pages 47-65

  • HLA Typing by Direct DNA Sequencing

    Smith, Linda K.

    Pages 67-86

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-1-61779-842-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-1-61779-841-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunogenetics
Book Subtitle
Methods and Applications in Clinical Practice
Editors
  • Frank T. Christiansen
  • Brian D. Tait
Series Title
Methods in Molecular Biology
Series Volume
882
Copyright
2012
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-61779-842-9
DOI
10.1007/978-1-61779-842-9
Hardcover ISBN
978-1-61779-841-2
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVI, 689
Number of Illustrations and Tables
135 b/w illustrations, 2 illustrations in colour
Topics