Molecular and Integrative Toxicology

Immunotoxicity, Immune Dysfunction, and Chronic Disease

Editors: Dietert, Rodney R., Luebke, Robert W. (Eds.)

  • Emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s)
  • Describes suggested  environmental risk factors, underlying immune dysfunction(s) associated with the disease and the overall health consequences of the disease
  • Comprehensive in scope
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eBook $189.00
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  • ISBN 978-1-61779-812-2
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  • Immediate eBook download after purchase
Hardcover $249.00
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  • ISBN 978-1-61779-811-5
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Softcover $249.00
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  • ISBN 978-1-62703-926-0
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About this book

Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030.  The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases.

To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates from that prior model.  It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases. 

This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches.  Rather than considering environmental factors and types of reported immune alterations (e.g., depressed humoral immunity)  as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad  from the standpoint of the disease.  Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) (e.g., asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1)  the suggested  environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease. 

This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT).  The series will feature detailed research information, but in the context of a more integrative or holistic framework.   As part of this framework, the chapters will contain a section on  ”Key Points” as well as “Recommendations” where appropriate.  The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. 

We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions.   We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges.

About the authors

Rodney R. Dietert is Professor of Immunotoxicology at Cornell University, Ithaca, NY whose interests focus on the prevention of chronic diseases via patterns that first emerge in children.  Dietert’s recent books include: Strategies For Protecting Your Child's Immune System (World Scientific, Singapore, Hackensack, NJ, 2010) and Immunotoxicity Testing (as Editor) (Springer, NY, 2010). He previously directed Cornell's Program on Breast Cancer and Environmental Risk Factors and the Institute for Comparative and Environmental Toxicology and served as a Senior Fellow in Cornell’s Center for the Environment.  Dietert recently served on panels for the Institute of Medicine (Agent Orange), the WHO (Immunotoxicology Risk Assessment) and the EPA (Trichloroethylene). 

 

Robert W. Luebke is an immunotoxicologist with the U.S. Environmental Protection Agency in Research Triangle Park, NC whose research is focused on the consequences of exposure to environmental chemicals on immune system homeostasis and resistance to infectious disease, and the development of alternative testing methods for high throughput screening of chemicals for immune system toxicity.  He has authored numerous book chapters on immunotoxicology and immunotoxicology methods and served as senior editor of the third edition of Immunotoxicology and Immunopharmacology (CRC Press, Boca Raton, FL, 2007). Recent service activities include membership on a core writing group for the WHO Harmonized Immunotoxicity Risk Assessment Guidelines and the Organization for Economic Cooperation and Development’s Technical Guidance 443, the  Extended One-Generation Reproductive Toxicity Study.

Table of contents (17 chapters)

  • Introduction to Immunotoxicity

    Salazar, Keith D. (et al.)

    Pages 3-30

  • The Environment-Immune Route to Chronic Disease

    Dietert, Rodney R. (et al.)

    Pages 31-47

  • Asthma and Respiratory Allergic Disease

    Lehmann, David M. (et al.)

    Pages 51-101

  • Cutaneous Allergies

    Basketter, David A. (et al.)

    Pages 103-126

  • Food Allergies

    Bowman, Christal C.

    Pages 127-149

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-61779-812-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-61779-811-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-62703-926-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunotoxicity, Immune Dysfunction, and Chronic Disease
Editors
  • Rodney R. Dietert
  • Robert W. Luebke
Series Title
Molecular and Integrative Toxicology
Copyright
2012
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61779-812-2
DOI
10.1007/978-1-61779-812-2
Hardcover ISBN
978-1-61779-811-5
Softcover ISBN
978-1-62703-926-0
Series ISSN
2168-4219
Edition Number
1
Number of Pages
XVI, 452
Topics