Methods in Molecular Biology

Liver Stem Cells

Methods and Protocols

Editors: Ochiya, Takahiro (Ed.)

  • Includes topics that shed light on stem cell technology, leading to the development of effective clinical modalities for human liver diseases
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts.
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eBook $109.00
price for USA (gross)
  • ISBN 978-1-61779-468-1
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  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-61779-467-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4939-5910-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Increasing evidence suggests that liver stem cells have the capacity to differentiate into parenchymal hepatocytes or into bile ductular cells. These stem cells may be activated to proliferate after severe liver injury or exposure to hepatocarcinogens. Stem cell replacement strategies are being investigated as an alternative approach to liver repair and regeneration. Additionally, stem cell transplantation has been shown to significantly improve liver function and increase survival in experimentally-induced liver-injury models in animals. In Liver Stem Cells: Methods and Protocols, expert researchers focus on  several hepatic progenitor cells, hepatic differentiation form stem cells, bile ductal cell formation from stem cells, liver stem cells and hepatocarcinogenesi, and  application of liver stem cells for cell therapy.  These topics shed light on stem cell technology which may lead to the development of effective clinical modalities for human liver diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Thorough and intuitive, Liver Stem Cells: Methods and Protocols seeks to aid scientists in the further study of preclinical and clinical investigations that explore the therapeutic potential of stem cells in repair of liver injuries.

 

Reviews

From the reviews:

“The brief and concise preface written by Prof. Takahiro Ochiya is particularly well addressed to scholars belonging to different scientific fields: cellular and molecular biology, liver and cancer biology, tissue engineering and stem cell therapy. … This book is properly arriving on the desks of those interested in the biology of this organ that already from the Greeks times, as the myth of Prometheus revealed, possess a very high proliferative capacity (after an injury).” (CarloAlberto Redi, European Journal of Histochemistry, Vol. 57, 2013)

Table of contents (17 chapters)

  • Purification and Culture of Fetal Mouse Hepatoblasts that Are Precursors of Mature Hepatocytes and Biliary Epithelial Cells

    Shiojiri, Nobuyoshi (et al.)

    Pages 3-10

  • Clinical Uses of Liver Stem Cells

    Dan, Yock Young

    Pages 11-23

  • Identification and Isolation of Adult Liver Stem/Progenitor Cells

    Tanaka, Minoru (et al.)

    Pages 25-32

  • Isolation and Purification Method of Mouse Fetal Hepatoblasts

    Gailhouste, Luc

    Pages 33-47

  • Isolation of Hepatic Progenitor Cells from the Galactosamine-Treated Rat Liver

    Ichinohe, Norihisa (et al.)

    Pages 49-58

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-61779-468-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-61779-467-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4939-5910-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Liver Stem Cells
Book Subtitle
Methods and Protocols
Editors
  • Takahiro Ochiya
Series Title
Methods in Molecular Biology
Series Volume
826
Copyright
2012
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61779-468-1
DOI
10.1007/978-1-61779-468-1
Hardcover ISBN
978-1-61779-467-4
Softcover ISBN
978-1-4939-5910-5
Series ISSN
1064-3745
Edition Number
1
Number of Pages
X, 226
Topics