Methods in Molecular Biology

Kinase Inhibitors

Methods and Protocols

Editors: Kuster, Bernhard (Ed.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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  • ISBN 978-1-61779-337-0
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  • Immediate eBook download after purchase
Hardcover $149.00
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  • ISBN 978-1-61779-336-3
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Softcover $149.00
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  • ISBN 978-1-4939-5757-6
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About this book

Protein and lipid kinases are often the master regulators of cell signaling in eukaryotic systems. The human genome codes for more than 500 of these enzymes and their misregulation has been shown to be involved in the onset and progression of many diseases including cancer and inflammation. Therefore, small molecule kinase inhibitors have become important research tools for the elucidation of the many biological roles of kinases and their mechanisms of action. Kinase inhibitors thus also contribute significantly to the drug pipelines of the pharmaceutical and biotechnology industries and to the growing need to treat cancer and inflammation. In Kinase Inhibitors: Methods and Protocols, experts in kinase biology, drug discovery, and clinical research present a series of exemplary methods that can be used to address the many challenges facing scientists in the discovery and development of kinase inhibitors both for research and clinical use. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and accessible, Kinase Inhibitors: Methods and Protocols aims to provide scientists with modern and relevant methods to accelerate or strengthen their research and drug discovery programs through the utilization of these vital regulators.

Reviews

From the reviews:

“This well-organized book is highly recommended to those who are interested in kinase inhibitors in both basic research and clinical practice. It is intended to provide an easily accessible collection of methods and strategies in the discovery and development of kinase inhibitors for research and clinical applications. … chapters include a background and introduction, a list of materials required, and a detailed step-by-step description of the methods including highlights of key steps in the procedure.” (Thomas L. Pazdernik, Doody’s Book Reviews, March, 2012)

Table of contents (16 chapters)

  • Targeting Cancer with Small-Molecular-Weight Kinase Inhibitors

    Fabbro, Doriano (et al.)

    Pages 1-34

  • Small-Molecule Protein and Lipid Kinase Inhibitors in Inflammation and Specific Models for Their Evaluation

    Gaestel, Matthias (et al.)

    Pages 35-44

  • Measuring the Activity of Leucine-Rich Repeat Kinase 2: A Kinase Involved in Parkinson’s Disease

    Lee, Byoung Dae (et al.)

    Pages 45-54

  • Measuring PI3K Lipid Kinase Activity

    Ciraolo, Elisa (et al.)

    Pages 55-67

  • A Fluorescence Polarization Assay for the Discovery of Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1

    Reindl, Wolfgang (et al.)

    Pages 69-81

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-61779-337-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.00
price for USA
  • ISBN 978-1-61779-336-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.00
price for USA
  • ISBN 978-1-4939-5757-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Kinase Inhibitors
Book Subtitle
Methods and Protocols
Editors
  • Bernhard Kuster
Series Title
Methods in Molecular Biology
Series Volume
795
Copyright
2012
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61779-337-0
DOI
10.1007/978-1-61779-337-0
Hardcover ISBN
978-1-61779-336-3
Softcover ISBN
978-1-4939-5757-6
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 256
Topics