Methods in Molecular Biology

In Silico Tools for Gene Discovery

Editors: Yu, Bing, Hinchcliffe, Marcus (Eds.)

  • Provides brief introductions and clear instructions for the applications of each particular in silico tool
  • Features a wide variety of tools with easy to follow methodologies
  • Includes key tips and vital implementation advice straight from the experts
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-61779-176-5
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  • Immediate eBook download after purchase
Hardcover $169.00
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About this book

As functional genomics has become one of the major focuses in molecular biology, the need for more sophisticated tools to assist in the identification of the functionality of undefined genes and the correlation of DNA variants with a particular phenotype has increased greatly.  In Silico Tools for Gene Discovery collects many common and useful in silico tools available today.  The volume begins by investigating locus mapping information on linkage analysis, association mapping, integrative analysis, and exome analysis as well as tools for DNA marker selection, in silico PCR, and statistical analysis.  It continues with a section on gene discovery from a defined locus, including gene prioritization, knowledge tracking, and data mining, and concludes with several useful in silico tools presented for the functional characterization of genes, which include DNA sequencing analysis, variant characterization, as well as RNA and protein  analysis.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, step-by-step, readily reproducible protocols, and vital notes on troubleshooting and avoiding known pitfalls.

 

Resourceful and easy to follow, In Silico Tools for Gene Discovery seeks to facilitate scientists with further key research on locus mapping, to accelerate gene identification, and to help ascertain the functionality of DNA variation.

Table of contents (21 chapters)

  • Accessing and Selecting Genetic Markers from Available Resources

    Bell, Christopher G.

    Pages 1-17

  • Linkage Analysis

    Barrett, Jennifer H. (et al.)

    Pages 19-33

  • Association Mapping

    Painter, Jodie N. (et al.)

    Pages 35-52

  • The ForeSee (4C) Approach for Integrative Analysis in Gene Discovery

    Guo, Yike (et al.)

    Pages 53-71

  • R Statistical Tools for Gene Discovery

    Foulkes, Andrea S. (et al.)

    Pages 73-90

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-61779-176-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-61779-175-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
In Silico Tools for Gene Discovery
Editors
  • Bing Yu
  • Marcus Hinchcliffe
Series Title
Methods in Molecular Biology
Series Volume
760
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61779-176-5
DOI
10.1007/978-1-61779-176-5
Hardcover ISBN
978-1-61779-175-8
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 365
Topics