Neuromethods

Animal Models of Schizophrenia and Related Disorders

Editors: O'Donnell, Patricio (Ed.)

  • Explores the use of animal models in this difficult area of study and shows how the use of these models is greatly paying off in solid research
  • Features practical methodologies, ready for laboratory implementation
  • Covers the key areas of research being undertaken today
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-61779-157-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-61779-156-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Animal models of schizophrenia and other major psychiatric disorders have been sought for decades, and, as a result, we are now facing new vistas on pathophysiology that could lead to novel therapeutic approaches and even hint at possible preventive strategies. Animal Models of Schizophrenia and Related Disorders presents an overview of the information that can be obtained with several different models and a detailed account of how to generate such models in order to ensure that the manipulations used to model schizophrenia-relevant phenomena are used consistently across laboratories.  This detailed volume features pharmacological models such as non-competing NMDA antagonists, emphasizing their use in vitro, neurodevelopmental models such as the neonatal ventral hippocampal lesion and the antimitotic MAM, models that reproduce environmental factors such as neonatal hypoxia, vitamin D deficits, and prenatal immune activation, as well as several different genetic model approaches.  As a volume in the Neuromethods series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results.

 

Practical and cutting-edge, Animal Models of Schizophrenia and Related Disorders highlights the successes in the use of animal models to gain insight on pathophysiological mechanisms of relevance to major psychiatric disorders in the hope of inspiring investigators to expand the research and test targets that could restore or ameliorate function.

Reviews

From the reviews:

“The chapters address important and possibly tractable targets such as prepulse inhibition and GABAergic dysregulation that may help advance the field. … Written and edited by leaders in this field, this overview of animal models in psychosis would be of interest to researchers. … This book reflects the current state of affairs in this field of research … .” (Michael Joel Schrift, Doody’s Book Reviews, November, 2011)

Table of contents (12 chapters)

  • A Method to the Madness: Producing the Neonatal Ventral Hippocampal Lesion Rat Model of Schizophrenia

    Chambers, R. Andrew (et al.)

    Pages 1-24

  • Gestational MAM (Methylazoxymethanol) Administration: A Promising Animal Model for Psychosis Onset

    Pen, Gwenaëlle (et al.)

    Pages 25-77

  • Prenatal Infection and Immune Models of Schizophrenia

    Brown, Alan S.

    Pages 79-91

  • The Hypoxic Rat Model for Obstetric Complications in Schizophrenia

    Schmitt, Andrea (et al.)

    Pages 93-111

  • The Developmental Vitamin D (DVD) Model of Schizophrenia

    Eyles, Darryl W. (et al.)

    Pages 113-125

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-61779-157-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-61779-156-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Animal Models of Schizophrenia and Related Disorders
Editors
  • Patricio O'Donnell
Series Title
Neuromethods
Series Volume
59
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61779-157-4
DOI
10.1007/978-1-61779-157-4
Hardcover ISBN
978-1-61779-156-7
Series ISSN
0893-2336
Edition Number
1
Number of Pages
XII, 290
Number of Illustrations and Tables
51 b/w illustrations
Topics