Current Cancer Research

Chemical Carcinogenesis

Editors: Penning, Trevor M. (Ed.)

  • Focuses on chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action, the balance between metabolic activation to form biological reactive intermediates and their detoxification, and environmental agents that can promote tumor formation
  • Appeals to graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research
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  • ISBN 978-1-61737-995-6
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  • ISBN 978-1-61779-729-3
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About this book

This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code.  It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.

Table of contents (18 chapters)

  • Historical Overview of Chemical Carcinogenesis

    Harvey, Ronald G.

    Pages 1-26

  • Multistage Carcinogenesis

    Abel, Erika L. (et al.)

    Pages 27-51

  • Tobacco Smoke Carcinogens and Lung Cancer

    Hecht, Stephen S.

    Pages 53-74

  • Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products

    Bolton, Judy L.

    Pages 75-93

  • Heterocyclic Aromatic Amines: Potential Human Carcinogens

    Turesky, Robert J.

    Pages 95-112

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-61737-995-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-61737-994-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61779-729-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Chemical Carcinogenesis
Editors
  • Trevor M. Penning
Series Title
Current Cancer Research
Copyright
2011
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-61737-995-6
DOI
10.1007/978-1-61737-995-6
Hardcover ISBN
978-1-61737-994-9
Softcover ISBN
978-1-61779-729-3
Series ISSN
2199-2584
Edition Number
1
Number of Pages
XVI, 440
Topics