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Chemical Carcinogenesis

  • Book
  • © 2011

Overview

Editors:
  1. Trevor M. Penning

    1. School of Medicine, Dept. Pharmacology, University of Pennsylvania, Philadelphia, USA

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  • Focuses of this volume: chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action, the balance between metabolic activation to form biological reactive intermediates and their detoxification, and environmental agents that can promote tumor formation
  • appeals to graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research

Part of the book series: Current Cancer Research (CUCR)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Historical Overview of Chemical Carcinogenesis

    • Ronald G. Harvey
    Pages 1-26

  3. Multistage Carcinogenesis

    • Erika L. Abel, John DiGiovanni
    Pages 27-51

  4. Tobacco Smoke Carcinogens and Lung Cancer

    • Stephen S. Hecht
    Pages 53-74

  5. Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products

    • Judy L. Bolton
    Pages 75-93

  6. Heterocyclic Aromatic Amines: Potential Human Carcinogens

    • Robert J. Turesky
    Pages 95-112

  7. Aflatoxin and Hepatocellular Carcinoma

    • John D. Groopman, Gerald N. Wogan
    Pages 113-133

  8. Metabolic Activation of Chemical Carcinogens

    • Trevor M. Penning
    Pages 135-158

  9. Detoxication of Chemical Carcinogens and Chemoprevention

    • Melinda S. Yates, Thomas W. Kensler
    Pages 159-179

  10. Covalent Polycyclic Aromatic Hydrocarbon–DNA Adducts: Carcinogenicity, Structure, and Function

    • Suse Broyde, Lihua Wang, Yuqin Cai, Lei Jia, Robert Shapiro, Dinshaw J. Patel et al.
    Pages 181-207

  11. Oxidation and Deamination of DNA by Endogenous Sources

    • Peter C. Dedon
    Pages 209-225

  12. Lipid Peroxide–DNA Adducts

    • Seon Hwa Lee, Ian A. Blair
    Pages 227-244

  13. Chemical Carcinogenesis and Epigenetics

    • Agus Darwanto, Jonathan D. Van Ornam, Victoria Valinluck Lao, Lawrence C. Sowers
    Pages 245-266

  14. Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies

    • Ye Peng, Hong Wang, Lucas Santana-Santos, Caroline Kisker, Bennett Van Houten
    Pages 267-296

  15. Base-Excision Repair: Role of DNA Polymerase β in Late-Stage Base Excision Repair

    • Kenjiro Asagoshi, Samuel H. Wilson
    Pages 297-319

  16. O 6-Alkylguanine-DNA Alkyltransferase

    • Anthony E. Pegg, Sreenivas Kanugula, Natalia A. Loktionova
    Pages 321-343

  17. Bypass DNA Polymerases

    • Jeong-Yun Choi, Robert L. Eoff, F. Peter Guengerich
    Pages 345-373

  18. Mutagenesis: The Outcome of Faulty Replication of DNA

    • Ashis K. Basu
    Pages 375-399

  19. p53 and Ras Mutations in Cancer and Experimental Carcinogenesis

    • Zahidur Abedin, Sushmita Sen, Elise Morocco, Jeffrey Field
    Pages 401-422

  20. Back Matter

    Pages 423-440
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Keywords

About this book

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Editors and Affiliations

  • School of Medicine, Dept. Pharmacology, University of Pennsylvania, Philadelphia, USA

    Trevor M. Penning

Bibliographic Information

  • Book Title: Chemical Carcinogenesis

  • Editors: Trevor M. Penning

  • Series Title: Current Cancer Research

  • DOI: https://doi.org/10.1007/978-1-61737-995-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2011

  • Hardcover ISBN: 978-1-61737-994-9Published: 03 March 2011

  • Softcover ISBN: 978-1-61779-729-3Published: 19 April 2013

  • eBook ISBN: 978-1-61737-995-6Published: 03 March 2011

  • Series ISSN: 2199-2584

  • Series E-ISSN: 2199-2592

  • Edition Number: 1

  • Number of Pages: XVI, 440

  • Topics: Cancer Research, Pharmacology/Toxicology

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