Methods in Molecular Biology

Disease Gene Identification

Methods and Protocols

Editors: DiStefano, Johanna K. (Ed.)

  • Presents detailed laboratory procedures in an easy-to-follow format, accessible to graduate students, post-doctoral researchers, and bench scientists
  • Features readily reproducible protocols along with tips on troubleshooting
  • Based upon expert personal experience to ensure successful implementation
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-61737-954-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-61737-953-6
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About this book

Recent efforts to characterize genetic variation in the human genome, coupled with the rapidly developing field of genomics, have lead directly to the development of new and innovative approaches to the identification of genes contributing to complex human diseases. In Disease Gene Identification: Methods and Protocols, expert researchers in the field provide up-to-date molecular methodologies used in the process of identifying a disease gene, from the initial stage of study design to the next stage of preliminary locus identification, and ending with stages involved in target characterization and validation. As a volume in the highly successful Methods in Molecular Biology™ series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and detailed tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, Disease Gene Identification: Methods and Protocols seeks to aid scientists striving toward the identification and characterization of the many disease-related genes, which may someday pave the way for more accurate and improved methods of disease diagnosis as well as vital strategies for disease treatment and prevention.

Reviews

From the reviews:

“This is an excellent resource for innovative approaches to the identification of genes contributing to complex human diseases. … presenting detailed laboratory procedures in an easy-to-follow format that can be carried out successfully by competent experts lacking exposure to a specific research method. … will be useful for clinicians such as oncologists interested in learning about gene identification. … an excellent resource for graduate students, postdoctoral researchers, bench scientists, clinical oncologists, and hematologists interested in the fields of molecular genetics and molecular biology.” (Omer Iqbal, Doody’s Review Service, June, 2011)

Table of contents (20 chapters)

  • Technological Issues and Experimental Design of Gene Association Studies

    DiStefano, Johanna K. (et al.)

    Pages 3-16

  • Statistical Issues in Gene Association Studies

    Watanabe, Richard M.

    Pages 17-36

  • Identification of Causal Sequence Variants of Disease in the Next Generation Sequencing Era

    Kingsley, Christopher B.

    Pages 37-46

  • Microarray-Based Genome-Wide Association Studies Using Pooled DNA

    Szelinger, Szabolcs (et al.)

    Pages 49-60

  • Medium-Throughput SNP Genotyping Using Mass Spectrometry: Multiplex SNP Genotyping Using the iPLEX® Gold Assay

    Millis, Meredith P.

    Pages 61-76

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-61737-954-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-61737-953-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Disease Gene Identification
Book Subtitle
Methods and Protocols
Editors
  • Johanna K. DiStefano
Series Title
Methods in Molecular Biology
Series Volume
700
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61737-954-3
DOI
10.1007/978-1-61737-954-3
Hardcover ISBN
978-1-61737-953-6
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 312
Topics